GW0742 Sarms Ua nyob rau hauv Tuam Tshoj High -purity Raw Powder

GW0742 Raw Khoom Powder Core Taw Qhia

Pharmaceutical -qib raw khoom|Ua nyob rau hauv Suav teb GW0742 (PPARδ agonist)

Tshuaj npe: (2S)-2-(4-{[(1,1'-diphenyl)-2-yl]amino}phenyl)propionic acid

CAS Nr.: 317318-70-0

EINECS ID: -

Cov mis mos molecular: C₂₁H₁₉F₃N₂O₃S

Molecular hnyav: 424.45

Melting pointKub: 189-192 degree

Qhov tshwm sim: Dawb crystalline hmoov

Purity: Ntau dua lossis sib npaug li 99% (HPLC kuaj pom)

Cov teebmeem tseem ceeb

GW0742 yog ibxaiv PPARδ agonist heevuas yog dav siv nyob rau hauvKev tshawb nrhiav kab mob metabolic, kev tawm dag zog kev txhim kho, thiab txhim kho cov leeg nqaijvim nwstshwj xeeb peroxisome proliferator-activated receptor δ- tswj cov khoom.

✅Metabolickev cai mechanism:

PPARδ kev ua haujlwm: Muaj kev xaiv ua kom lub PPARδ nuclear receptor, EC50=1 nM

Fatty acid oxidation: Txhawb fatty acid -oxidation, nce zog siv.

Txhim kho glucose metabolism: Txhim kho insulin rhiab heev thiab tswj cov piam thaj metabolism

✅Qualityqhov zoo ntawm Suav manufacturing:

Purity Guarantee: Raw khoom purity Ntau dua los yog sib npaug rau 99.5%, ua raws li USP cov qauv.

Chirality tswj: (S)-configuration optical purity Ntau dua lossis sib npaug li 99.8%

Zoo heev stability: Purity tseem siab dua 97% tom qab 6 lub hlis ntawm kev ntsuas nrawm.

✅ thoob ntiaj tebmuab kev ruaj ntseg:

Cold chain logistics: -20℃txias saw tsheb thauj mus los thoob plaws tag nrho cov txheej txheem los xyuas kom meej cov khoom ruaj khov.

Ntau- khoom xa tuaj: Cov tsev khaws khoom hauv cheeb tsam tau tsim nyob rau hauv Suav teb, Tebchaws Europe, Amelikas, thiab Asia - cheeb tsam Pacific, ua kom cov khoom xa tuaj hauv 7 hnub.

Kev them nyiaj yug kev lis kev cai clearance: Kev npaj cov ntaub ntawv ua kom muaj kev lis kev cai zoo thoob ntiaj teb.

Cov txheej txheem ntau lawm thiab kev ruaj ntseg zoo

1. Advanced synthesis txheej txheem:

Chiral synthesis: Asymmetric synthesis, (S)-configuration optical purity Ntau dua los yog sib npaug rau 99.8%

Kev ua kom huv huv: Npaj HPLC purification, gradient elution, sau ntawm lub ntsiab ncov.

Tshuab ziab khaub ncaws: Lub tshuab nqus tsev qis- kub kom qhuav, noo noo cov ntsiab lus tsawg dua lossis sib npaug li 0.5%

2. Cov qauv kev tswj xyuas nruj:

Tshuaj purity:

Cov ntsiab lus tseem ceeb: 99.0% ~ 101.0%

Cov khoom muaj feem xyuam: Ib qho impurity Tsawg dua lossis sib npaug li 0.1%, tag nrho impurities Tsawg dua lossis sib npaug li 0.5%

Residual solvent: Ua raws li ICH Q3C cov qauv

Lub cev muaj zog:

Particle loj faib: D50 50-100μm

Qhov ceev: 0.4-0.6 g / cm³

Solubility: Ua tau raws li cov qauv rau cov khoom xyaw tshuaj nquag.

3. Cov ntaub ntawv ruaj ntseg:

Ntev -lub sij hawm ruaj khov: Khaws ntawm -20℃rau 24 lub hlis, txhua qhov ntsuas tau ua tau raws li qhov xav tau.

Kev ntsuas nrawm: Tom qab khaws cia ntawm 25℃rau 6 lub hlis, purity txo qis dua los yog sib npaug li 2.0%.

Kev thauj mus los ruaj khov: Kev vibration thiab poob kev xeem dhau.

Cov yam ntxwv ntawm daim ntawv thov thiab qhov zoo

1. Cov yam ntxwv ua tau zoo:

Endurance Txhim Kho: Txhim khu kev ua kom muaj zog thiab ua kom cov pa oxygen ntau tshaj.

Txo rog: Txhawb cov roj oxidation thiab txo lub cev rog.

Kev txhim kho metabolic: Txhim kho cov ntshav qab zib tswj thiab kev nkag siab ntawm insulin

2. Cov yam ntxwv tseem ceeb thiab qhov zoo:

Kev xaiv siab: 1000 npaug ntau dua xaiv rau PPARδ dua li PPAR thiab PPAR .

Kev tswj hwm metabolic: regulating fatty acid oxidation thiab lub zog metabolism

Zoo kev nyab xeeb profile: Cov kev tshawb fawb preclinical tau qhia txog kev nyab xeeb zoo.

3. Qhov zoo ntawm kev siv:

Siv tau qhov ncauj: Siab qhov ncauj bioavailability thiab yooj yim rau siv.

Cov ntawv thov tshawb fawb: Cov cuab yeej zoo tshaj plaws rau kev tshawb fawb hauv cov kab mob metabolic thiab cov tshuaj kis las.

Muaj peev xwm heev: Kev kho muaj peev xwm rau cov kab mob metabolic thiab hom 2 mob ntshav qab zib

Vim li cas thiaj xaiv Suav - ua GW0742 ?

Siabxaiv xaiv: PPARδ selectivity yog 1000 zaug siab dua PPAR / selectivity.

Chiralkev huv: (S)-configuration optical purity Ntau dua lossis sib npaug li 99.8%

Tshwj xeebkev huv: Tshaj 99% siab purity, nrog kev tswj xyuas nruj.

ruaj khovmuab: Ib qho kev xa khoom tiav ua kom muaj kev xa khoom raws sij hawm thiab txhim khu kev qha.

Cov ntsiab lus

Ua nyob rau hauv Suav teb, GW0742 raw khoom hmoovsawv cev rau qib siab - tus qauv zoo ntawm PPARδ agonists uas muaj kev xaiv zoo heev. Los ntawmadvanced chiral synthesis thev naus laus zis, kev tswj xyuas zoo, thiab cov khoom siv ruaj khov,nws muabsiab -cov cuab yeej tshawb fawb zoo heevrauCov kab mob metabolic thoob ntiaj teb thiab kev tshawb fawb tshuaj ncaws pob. Xaiv Ua hauv Suav teb txhais tau tias xaivkev tshawb fawb-qib zoo thiab txhim khu kev qha.

Xav taudab tsi, thov hu raupeb

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