HGH 176/191 (fragment) 2mg / vial Targeted Promotion Of Fat Metabolism

Kev loj hlob hormone fragment 176-191 2mg/bottle core introduction

Tib neeg txoj kev loj hlob hormone active fragment|Amino acid sequence 176-191 2mg/vial

Lub npe: Loj hlob hormone tso peptide 176-191

Ib ntus: H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-S er-Val-Glu-Gly-Ser-Cys-Gly-Ph-OH

Molecular hnyav: Kwv yees li 1817.0 Da

Purity: Ntau dua lossis sib npaug li 98.5% (HPLC)

Cov ntsiab lus: 2mg / lub raj mis

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: Txias ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab khaws cia

Kev loj hlob hormone fragments 176-191:

Qhov loj hlob hormone fragment 176-191 yog ib ntu ntawm C-qhov kawg ntawm tib neeg kev loj hlob hormone. Nws khaws cov kev ua haujlwm lom neeg ntawm stimulating lipolysis tab sis ua rau yuav luag tsis muaj qhov anabolism, pob txha loj hlob, thiab glycemic cuam tshuam ntawm tag nrho -ntev loj hlob hormone. Tsis zoo li kev loj hlob hormone tag nrho, qhov 16-peptide fragment tshwj xeeb txhawb nqa -3 adrenergic receptors hauv cov ntaub so ntswg adipose, txhawb lipolysis, tsis muaj kev cuam tshuam rau kev loj hlob hormone receptors los ua rau muaj kev cuam tshuam hauv lub cev. Nws qhov tshwj xeeb "kev xaiv lipolysis" tus yam ntxwv ua rau nws muaj txiaj ntsig kev tshawb fawb tseem ceeb hauv kev kawm txog kev txo cov rog hauv cheeb tsam, kev tswj cov metabolism, thiab cov txheej txheem ntawm kev kho mob rog.

Vim nws qhov zoo -txhais tau xaiv cov rog rog, kev loj hlob hormone fragment 176-191 yog qhov kev xaiv zoo tshaj plaws rau cov kws tshawb fawb hauv ntau qhov kev tshawb fawb metabolic, kev kho mob rog, thiab tshawb xyuas cov txheej txheem ntawm kev txo cov rog hauv zos. Nws tsis ua los ntawm classic GH-IGF-1 axis, zam cov kev mob tshwm sim uas yuav tshwm sim nrog kev loj hlob tsis zoo, xws li acromegaly, nce ntshav qab zib, thiab edema. Nws lub hom phiaj tshwj xeeb ntawm adipocytes ua rau nws yog ib qho cuab yeej tshawb fawb uas tsis tshua muaj kev pheej hmoo ntawm kev mob tshwm sim thaum kawm cov txheej txheem molecular ntawm refractory fat metabolism, cov rog hauv cheeb tsam, thiab cov kab mob metabolic.

Kev siv ntawm kev loj hlob hormone fragments 176-191:

Nws tshwj xeeb txhawb kev tawg ntawm triglycerides hauv adipocytes thiab txhawb kev tso tawm ntawm cov roj fatty acids uas tsis muaj kev cuam tshuam rau pob txha loj hlob lossis cov piam thaj metabolism. Kev loj hlob hormone fragment 176-191 yog polypeptide nrog kev xaiv lipolysis muaj nuj nqi, ua rau nws yog ib qho cuab yeej zoo rau kev kawm txog kev tswj hwm cov txheej txheem ntawm lipid metabolism.

Loj hlob hormone fragments 176-191 yog dav siv nyob rau hauv kev tshawb fawb ntawm lipid metabolism, lub pathophysiological mechanisms ntawm rog, thiab localized rog txo cov tswv yim. Lawv cov teebmeem tshwj xeeb ntawm cov ntaub so ntswg adipose muab cov qauv kev tshawb fawb tshwj xeeb rau kev tshawb nrhiav adipocyte signaling pathways, hormone-sensitive lipase activation mechanisms, thiab lub hauv paus molecular ntawm lub regional fat deposition. Lawv kuj tseem muaj qhov tseem ceeb hauv kev ntsuam xyuas cov tshuaj txo cov rog tshiab thiab kawm txog cov teebmeem metabolic ntawm kev tawm dag zog thiab kev noj zaub mov zoo.

Txoj kev siv thiab khaws cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Nyiam cov kuab tshuaj: sterile dej rau kev txhaj tshuajlos yogsterile phosphate tsis muaj pH 7.0-7.5

Kev ruaj ntseg optimization: Sterile PBS muaj 0.1% bovine serum albumin (BSA)

Rau kev sim tsiaj: Dilute nrog sterile physiological saline.

Tus txheej txheem npaj:

Solvent npaj:

Cov kuab tshuaj tau lim los ntawm 0.22 μm lim membrane.

Rov qab cov kuab tshuaj mus rau chav sov (20-25 degree).

Reconstitution txheej txheem:

Ntxiv 1.0 mL ntawm cov kuab tshuaj pom zoo rau 2 mg vial.

Maj mam ncuav cov hmoov raws lub raj mis phab ntsa kom tsis txhob cuam tshuam ncaj qha rau cov hmoov.

Maj mam tig lub vial rau 2-3 feeb kom txog thaum yaj tag.

Qhov kawg concentration: 2 mg / mL (kwv yees li 1.1 mM)

Dispensing thiab dilution:

Tam sim ntawd aliquot rau hauv 20-50 μL feem siv cov cryovials qis.

Dilute rau kev ua haujlwm siab nrog PBS lossis physiological saline uas muaj 0.1% BSA.

Clear labeling: Khoom npe, concentration, npaj hnub

Ua hauj lwm concentration/dosage reference:

Kev sim hauv vitro cell: Feem ntau siv cov concentration ntau yog 0.1 μM txog 10 μM

Tsiaj hauv vivo sim: Feem ntau siv ntau npaum li cas yog 50 ug / kg txog 300 ug / kg (subcutaneous txhaj).

Kev kawm txhaj tshuaj hauv zos: concentration 50-200 ug / mL, 10-50 μL txhaj ntawm txhua qhov chaw.

Piv txwv ntawm kev npaj xam: Yog tias xav tau 10 μM kev ua haujlwm, siv 9.1 μL ntawm cov tshuaj hauv Tshuag thiab ntxiv rau 1 mL ntawm kab lis kev cai nruab nrab.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Cov txheej txheem aseptic: Tag nrho cov txheej txheem npaj tau ua tiav hauv lub txee biosafety.

Lub teeb zam kev xav tau: Sensitive rau lub teeb, yuav tsum tuav hauv qhov tsaus ntuj.

Solubility: Soluble zoo nyob rau hauv dej thiab buffer ntsev daws.

Kom tsis txhob adsorption: siv cov tshuaj uas muaj cov kab mob cab rau cov kuab tshuaj kom txo tau cov adsorption poob ntawm phab ntsa raj.

Npaj thiab siv tam sim ntawd: Nws raug pom zoo kom siv tsis pub dhau 4 teev tom qab hloov kho.

Kov maj mam: Tsis txhob ua nruj ua tsiv uas yuav ua rau muaj cua npuas.

2. Cia tej yam kev mob:

Unreconstituted lyophilized hmoov:

Ntev - lub sij hawm cia: Frozen ntawm -20 degree, txee lub neej 24 lub hlis

Kev cia zoo: -80℃(ntub khov), txee lub neej 36 lub hlis.

Kev tiv thaiv lub teeb yuav tsum: Khaws rau hauv lub hnab ntawv aluminium qub kom deb ntawm lub teeb.

Cov dej noo- pov thawj cia: Ua-hauv desiccant, txheeb ze av tsawg dua los yog sib npaug li 50%.

Reconstituted daws:

tam sim ntawdtom qab kev kho dua tshiab rau kev ua haujlwm zoo.

Short - lub sij hawm cia: Txias ntawm 2-8℃tsis pub ntau tshaj 12 teev.

Repacking thiab khov: Rov ntim thiab khov ntawm -20℃tsis pub ntau tshaj 1 lub hlis.

Txias -thaw txwv: Qhov siab tshaj plaws ntawm 2 khov -thaw cycles raug tso cai.

Kev thauj mus los:

Kev thauj mus los txiasCov dej khov qhuav qhuav (hauv qab -78 degree)

luv - tsheb thauj mus losKev thauj mus los: 2-8℃ice pob, tsis pub dhau 24 teev.

Ntim txheem: Lub teeb- pov thawj aluminium foil hnab + lub tshuab nqus tsev foob + insulated lub thawv

Shipping labeling: Qhia meej meej "Bioactive Peptides", "Tsuas Kub", thiab "Tshem Tawm ntawm Lub Teeb".

3. Tswj kev ruaj ntseg:

Kub stability:

-80℃: >3 xyoo

-20℃: >2 xyoo

2-8 degree: Tsawg dua lossis sib npaug li 12 teev (kev daws teeb meem)

Chav ntsuas kub: Tsawg dua lossis sib npaug li 4 teev (kev daws teeb meem)

Tshuaj stability:

Qhov zoo tshaj pH ntau: 6.5-7.5

Tsis txhob muaj cov kua qaub uas muaj zog, muaj zog alkalis, thiab cov tshuaj oxidizing.

Lub cev ruaj khov:

Tsis txhob ua nruj ua tsiv

Tsis txhob rov khov dua -thaw cycles

Tsis txhob kub siab thiab hluav taws xob ultraviolet.

Kev kho ntawm bioactivity:

Siv cov khoom siv tsawg-absorption

Ntxiv cov cab kuj protein txo cov adsorption nonspecific

Kho qhov khov -thaw txheej txheem

Xav taudab tsi, thov hu raupeb

Cim npe nrov: Hgh 176/191 (fragment) 2mg / vial tsom kev txhawb nqa cov roj metabolism, Tuam Tshoj hgh 176/191 (fragment) 2mg / vial tsom kev txhawb nqa cov roj metabolism manufacturers, lwm tus neeg, Hoobkas