Melatonin 10mg / vial Txhim kho kev pw tsaug zog zoo

Melatonin 10mg / lub raj mis qhia

High -purity melatonin raw khoom|Ua nyob rau hauv Suav teb, pineal hormone 10mg / lub raj mis

Lub npe: Melatonin

Tshuaj npe: N-acetyl-5-methoxytryptamine

English npe: Melatonin

CAS Nr.: 73-31-4

Cov mis mos molecular: C₁₃H₁₆N₂O₂

Molecular hnyavYog ': 232.28 g/mol

Melting pointKub: 116-118 degree

Qhov tshwm sim: Dawb rau tawm -dawb crystalline hmoov

Purity: Ntau dua lossis sib npaug li 99.5% (HPLC)

Tshwj xeeb curl: Ua tau raws li qhov yuav tsum tau ua

Cia: Txias ntawm 2-8 degree, deb ntawm lub teeb, kaw, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Nyiam cov kuab tshuaj: anhydrous ethanollos yogDMSO (dimethyl sulfoxide)

Secondary kuab tshuaj: propylene glycol, PEB 400

Dej-kev npaj: Ua ntej yaj hauv me me ntawm ethanol lossis DMSO, tom qab ntawd ntxiv physiological saline uas muaj 0.1% Tween-80.

Tus txheej txheem npaj:

Kev npaj cov khoom lag luam:

Qhov tseeb hnyav 10mg ntawm melatonin siv qhov ntsuas ntsuas.

Ntxiv 1.0 mL ntawm anhydrous ethanol thiab maj mam vortex kom txog thaum yaj tag.

Ib qho kev daws teeb meem ntawm 10 mg / mL (kwv yees li 43 mM) tau txais.

Kev npaj ua haujlwm daws teeb meem:

Kev sim hauv vitro cell: Dilute nrog kab lis kev cai nruab nrab mus rau kev ua haujlwm siab ntawm 0.1-10 mM.

Tsiaj sim: Dilute nrog physiological saline muaj 0.1% Tween-80

Kev suav cov mis: Yuav tsum tau concentration × Yuav tsum ntim ntim ÷ Tshuag tshuaj concentration

Cais thiab khaws cia:

Tam sim ntawd muab tso rau hauv 50-100μL feem.

Labeling concentration, hnub npaj, thiab batch naj npawb.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Cov lus qhia txog kev tawg: Melatonin muaj cov solubility tsawg heev hauv dej (kwv yees li 0.1 mg / mL), thiab yuav tsum tau yaj siv cov kuab tshuaj organic ua ntej.

Kev tiv thaiv lub teeb: Txhua yam haujlwm yuav tsum tau ua nyob rau hauv lub teeb - tiv thaiv tej yam kev mob.

Kev tswj qhov kub thiab txias: Tsis txhob kub siab thaum lub sijhawm npaj.

Cov txheej txheem aseptic: Cov txheej txheem aseptic yuav tsum tau siv thaum siv hauv cell lossis tsiaj sim.

Kev ruaj ntseg: Cov tshuaj hauv Tshuag tseem ruaj khov rau ob peb lub hlis thaum khaws cia ntawm -20℃hauv qhov tsaus ntuj.

2. Cia tej yam kev mob:

Cov khoom siv tsis tau qhib:

Short - lub sij hawm cia: Txias ntawm 2-8 degree, deb ntawm lub teeb. Lub neej txee: 24 lub hlis.

Ntev - lub sij hawm cia: khov ntawm -20 degree, tiv thaiv los ntawm lub teeb, txee lub neej 36 lub hlis.

Cov dej noo- pov thawj cia: Ua-hauv desiccant, txheeb ze av tsawg dua los yog sib npaug li 60%.

Cov tshuaj npaj tau raws li hauv qab no:

Tshuag daws: Khaws khov ntawm -20℃deb ntawm lub teeb; txee lub neej 3-6 lub hlis.

Kev daws teeb meem: Npaj tshiab ua ntej siv, khaws cia ntawm 2-8℃tiv thaiv lub teeb kom tsis pub dhau 24 teev.

Cov xwm txheej kom zam: Tsis txhob rov khov dua -thaw cycles, zam lub hnub ci.

Kev thauj mus los:

Kev thauj mus los txias: thauj tub yees ntawm 2-8 degree

Lub teeb- pov thawj ntim: sealed aluminium foil hnab

Shockproofing: thauj mus rau hauv cov thawv ua npuas ncauj nrog cov pob khov nab kuab.

3. Cov Lus Qhia Txog Kev Npaj:

Cov txheej txheem xaiv cov kuab tshuaj:

Lub hom phiaj tshawb fawb txiav txim siab xaiv cov kuab tshuaj.

DMSO yog qhov kev xaiv zoo tshaj plaws rau kev kawm hauv vitro.

Lub propylene glycol / Tween-80 system yog txoj kev nyiam rau hauv vivo kev tshawb fawb.

Dissolving kauj ruam:

Ntxiv me me ntawm cov organic hnyav ua ntej

Ntxiv lub aqueous theem tom qab ua tiav dissolution.

Tsis txhob dissolving ncaj qha rau hauv dej

Concentration tswj:

Cov ntsiab lus ntawm cov tshuaj 10 mg / ml

Qhov kev daws teeb meem ua haujlwm yog nyob ntawm qhov kev sim tsim.

Qhov kawg concentration ntawm cov organic solvent yog tsawg dua los yog sib npaug rau 0.1%.

Kev tiv thaiv kev ruaj ntseg:

Tsis txhob ua haujlwm teeb

Tsawg kub cia

Tsis txhob oxidation

Khaws rau hauv ib lub thawv airtight

4. Kev tshawb fawb thiab daim ntawv thov:

Kev sim ntawm tes:

Kev daws teeb meem: 10 mg / mL DMSO tov

Ua haujlwm siab: 0.1-10mM

Thaum kawg DMSO concentration: Tsawg dua los yog sib npaug rau 0.1%

Tsiaj sim:

Intraperitoneal txhaj: Npaj nrog physiological saline uas muaj 0.5% sodium carboxymethyl cellulose.

Kev tswj qhov ncauj: Npaj nrog pob kws roj lossis txiv roj roj.

Qhov ntau npaum li cas: 1-50 mg / kg

Hauv vitro biochemical kev sim:

Npaj ncaj qha nrog anhydrous ethanol lossis DMSO

Cov concentration yuav tsum tau kho raws li kev sim xav tau.

Nco ntsoov qhov sib piv hnyav.

Zoo Zoo ntawm Tuam Tshoj Manufacturers

Cov khoom no yog tsim los ntawm Tuam Tshoj API (Active Pharmaceutical Ingredient) chaw tsim tshuaj paus, ua raws li cov qauv cGMP, thiab tsim tshwj xeeb rau kev tshawb fawb thiab kev lag luam tshuaj.

✅ Advancedntau lawm technology:

Tshuaj synthesis txoj kev: siv 5-methoxytryptamine acetylation txheej txheem

Chirality tswj: Ua kom pom tseeb purity Ntau dua lossis sib npaug li 99.9%

Crystallization thiab refining: Ntau yam recrystallizations los txhim kho purity

Cov khoom ntim tag nrho: tiv thaiv kev kis kab mob thiab degradation

✅ nrujkev tswj kom zoo:

Kev kuaj purity:

HPLC purity Ntau dua lossis sib npaug li 99.5%

Ib qho impurity Tsawg dua lossis sib npaug rau 0.1%

Tag nrho impurities Tsawg dua lossis sib npaug li 0.5%

Cov qauv kev pom zoo:

Infrared spectroscopy (IR) tsom xam

Nuclear magnetic resonance (NMR) proton / carbon spectrum

Mass spectrometry (MS) molecular luj pom zoo

Physicochemical zog:

Melting point: 116-118 degree

Curl tshwj xeeb: -25℃rau -30 degree

Poob ntawm ziab: Tsawg dua lossis sib npaug li 0.5%

Tswj impurity:

Yam khoom: 5-methoxytryptamine Tsawg dua los yog sib npaug rau 0.1%

Cov hlau hnyav: Tsawg dua lossis sib npaug li 10ppm

Residual solvent: Ua raws li ICH cov cai

Residue ntawm ignition: Tsawg dua los yog sib npaug rau 0.1%

Kev kuaj microbial:

Tag nrho cov kab mob suav: Tsawg dua lossis sib npaug rau 100 CFU / g

Pwm thiab poov xab: Tsawg dua lossis sib npaug li 10 CFU / g

Escherichia coli: Tsis pom

Salmonella: Tsis kuaj pom

✅Stabilitykawm:

Kev Ua Phem Txhaum Cai:

Kub kub: 60 degree, ruaj khov rau 10 hnub

Cov av noo siab: ruaj khov rau 10 hnub ntawm RH 92.5%

Lub teeb siv: 4500 Lx, stabilized tom qab 10 hnub

Kev ntsuas nrawm: ruaj khov rau 6 lub hlis ntawm 40℃/ RH75%.

Long - xeem: ruaj khov rau 24 lub hlis ntawm 25℃/ RH60%.

Tshuaj stability:

Ethanol tov yog ruaj khov rau 6 lub hlis thaum khaws cia ntawm -20 degree.

DMSO tov yog ruaj khov rau 6 lub hlis thaum khaws cia ntawm -20 degree.

✅ProfessionalNtim:

Cov ntaub ntawv ntim khoom: amber iav raj mis + butyl roj hmab stopper + txhuas- yas hau

Nitrogen purging tiv thaiv: tiv thaiv oxidative degradation

Kev ziab kom qhuav: Ua -hauv molecular sieve desiccant

Lub teeb- pov thawj tsim: kaw nrog ib lub hnab aluminium ntawv nyiaj sab nraud

Cov ntaub ntawv tiav: Daim ntawv lo suav nrog batch naj npawb, purity, thiab hnub tas sij hawm.

✅TechnicalTxhawb nqa:

Muab cov ntaub ntawv ua tiav zoo

Xws li COA, MSDS

Kev sab laj thiab kev txhawb nqa

Customized specifications kev pab cuam

Xav taudab tsi, thov hu raupeb

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