Dermorphin 5mg / vial Muaj Peev Xwm Rau Kev Muaj Peev Xwm Zoo

Dermorphin 5mg / lub raj mis qhia

Siab -purity corticomerol raw khoom|Ua nyob rau hauv Suav teb, muaj zog μ-opioid receptor agonist 5mg / lub raj mis

Lub npeTom ntej: Piperamide

English npe: Dermorphin

Amino acid ua ntu zus: H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂

CAS Nr.: 77614-16-5

Cov mis mos molecular: C₄₀H₅₀N₈O₁₀

Molecular hnyavYog ': 802,89 g/mol

Purity: Ntau dua lossis sib npaug li 98.0% (HPLC)

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: khov ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Nyiam cov kuab tshuaj: 1% aqueous acetic acid dawslos yog0.1M hydrochloric acid daws

Secondary kuab tshuaj: Sterile dej rau kev txhaj tshuaj(thov ua tib zoo mloog rau solubility).

Rau kev sim ntawm tes: dissolve nyob rau hauv me me ntawm dilute acid ua ntej, ces dilute nrog PBS los yog kab lis kev cai nruab nrab.

Tus txheej txheem npaj:

Solvent npaj:

Rov qab 1% acetic acid tov los yog dej tsis muaj menyuam mus rau chav sov.

Nws raug nquahu kom ntxiv 0.1% bovine serum albumin (BSA) kom txo qis adsorption.

Reconstitution txheej txheem:

Ntxiv 1.0 mL ntawm cov kuab tshuaj mus rau 5 mg vial.

Maj mam tig lub vial kom yaj tag nrho.

Qhov kawg concentration: 5 mg / mL (kwv yees 6.2 mM)

Cais thiab khaws cia:

Tam sim ntawd muab tso rau hauv 10-20 μL feem.

Daim ntawv lo concentration, hnub tim, batch

Kev npaj ua haujlwm daws teeb meem:

Kev sim hauv vitro cellUa hauj lwm concentration 0.1-10 nM

Kev tshawb fawb tsiaj: Pom zoo koob tshuaj 1-10 ug / kg

Nco tseg: Tsis txhob rov khov dua -thaw cycles; siv cov aliquots tshiab rau txhua qhov kev sim.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Dissolving tswv yim: Ib puag ncig acidic (pH 3-4) yog qhov tsim nyog rau kev tawg.

Tsis txhob adsorption: Siv cov kav dej uas muaj cov khoom adsorption tsawg

Cov txheej txheem aseptic: Cov txheej txheem aseptic nruj yuav tsum tau khaws cia thaum lub sijhawm npaj.

Siv tam sim ntawd: Siv nyob rau hauv 1 teev tom qab reconstitution.

Kev ceev faj txog kev nyab xeeb: Hnav hnab looj tes thiab daim npog qhov ncauj thaum ua haujlwm.

2. Cia tej yam kev mob:

Unreconstituted lyophilized hmoov:

Ntev - lub sij hawm cia: Khaws khov ntawm -20 degree, txee lub neej 24 lub hlis

Kev cia zoo: Khaws khov ntawm -80 degree; txee lub neej 36 lub hlis.

Kev tiv thaiv lub teeb: Khaws rau hauv lub hnab ntawv aluminium qub kom deb ntawm lub teeb.

Reconstituted daws:

Siv tam sim ntawd: Qhov zoo tshaj plaws siv tam sim ntawd tom qab kev npaj.

Short - lub sij hawm cia: Txias ntawm 2-8℃tsis pub ntau tshaj 4 teev.

Ntev - lub sij hawm cia: Aliquot thiab khov ntawm -20℃tsis pub ntau tshaj 1 lub hlis.

Kev thauj mus los:

Txias- cov hmoov qhuav: thauj nrog dej khov qhuav (hauv qab -78 degree).

luv - tsheb thauj mus losKev thauj mus los: Ice pack (2-8 degree)

Lub teeb- pov thawj ntim: Lub teeb- cov ntaub ntawv pov thawj yuav tsum tau siv.

3. Daim ntawv qhia txog kev npaj:

Cov txheej txheem xaiv cov kuab tshuaj:

Nyiam cov kua qaub acidic

Tsis txhob siv cov tshuaj alkaline buffer.

Pom zoo 1% acetic acid tov

Txoj kev tawg:

Ntxiv cov kuab tshuaj maj mam

Yooj yim rotational dissolution

Tsis txhob nruj oscillations

Concentration tswj:

Cov ntsiab lus ntawm cov tshuaj 5 mg / ml

Npaj cov tshuaj ua haujlwm tshiab txhua lub sijhawm.

Tsis txhob muaj dilution siab cia

Cov lus qhia cia:

Dispense ntim 10-20 μL

Ntshiab thiab ua tiav cov cim

Khaws cia rau hauv ib lub thawv kaw

4. Cov Lus Qhia Tshwj Xeeb:

Biosafety:

Ua haujlwm hauv lub fume hood tshwj xeeb

Tsis txhob kov daim tawv nqaij ncaj qha

Kev kho cov kua dej tshwj xeeb

ruaj khov:

Nws yog rhiab heev rau lub teeb thiab yuav tsum tau ceev kom deb ntawm lub teeb.

rhiab heev rau cua sov, tsis txhob kub siab.

rhiab heev rau enzymes, thov khaws cia kom zoo.

Kev sib haum xeeb:

Tau tshaj cov kuab tshuaj acidic

Tsis txhob kov cov oxidants

Nws tsis coexist nrog hlau ions

Zoo Zoo ntawm Tuam Tshoj Manufacturers

Cov khoom no yog tsim los ntawm cov kws tshaj lij peptide tsim tawm hauv Suav teb, nruj me ntsis ua raws li cov qauv cGMP, thiab nws qhov zoo tau mus txog qib siab thoob ntiaj teb.

✅ AdvancedSynthesis Technology:

Fmoc solid{0}}phase synthesis: siv microwave-pab thev naus laus zis

D-Amino Acid Proprietary Technology: Precise Introduction of D-Alanine

Ntau lawm: batch loj txog li 10 grams

Tag nrho automated tswj: kom ntseeg tau qhov tseeb synthesis

✅ nrujkev tswj kom zoo:

Kev kuaj purity:

HPLC purity Ntau dua lossis sib npaug rau 98.0%

Chiral purity D-Ala Ntau dua lossis sib npaug li 99.5%

Ib qho impurity Tsawg dua lossis sib npaug li 0.5%, tag nrho impurities Tsawg dua lossis sib npaug li 2.0%

Cov qauv kev pom zoo:

MALDI-TOF MS spectrometry tsom xam

Kev txheeb xyuas cov amino acid muaj pes tsawg leeg

Kev txheeb xyuas ib ntus

Bioactivity:

GPCR kev ua kom pom tseeb

IC₅₀ Tsawg dua lossis sib npaug rau 0.1nM

Xaiv Validation

Kev kuaj xyuas kev ruaj ntseg:

Cov kab mob endotoxin<10 EU/mg

Dhau qhov kuaj tsis muaj menyuam

Cov hlau hnyav<10ppm

Physicochemical zog:

Cov ntsiab lus noo noo tsawg dua lossis sib npaug li 5.0%

Cov ntsiab lus Peptide Ntau dua lossis sib npaug li 80.0%

Ua kom tiav solubility

✅Stabilitylav:

Kev ntsuas nrawm: ruaj khov rau 3 lub hlis ntawm 40℃/ 75% RH

Long - xeem: ruaj khov ntawm -20℃rau 24 lub hlis

Photostability: Nyob ruaj khov nyob rau hauv lub teeb - tiv thaiv tej yam kev mob

Thermal stability: Nyob ruaj khov nyob rau hauv lub tub yees txias

✅ProfessionalNtim:

Vial: Amber-xim lub teeb- thaiv iav

Sealing system: Fluorinated butyl roj hmab stopper

Nitrogen purging tiv thaiv: tiv thaiv oxidation

Kev ntim khoom ntawm tus kheej: Txhua tus neeg lub hnab aluminium + desiccant

Tag tag: Ua kom tiav cov ntaub ntawv ua lus Suav thiab Askiv

✅TechnicalTxhawb nqa:

Muab cov ntaub ntawv qhia txog kev ua tiav

Xws li COA, MSDS

Kev cai synthesis service

Kev them nyiaj yug technical

Xav taudab tsi, thov hu raupeb

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