GHRP-2 5mg/vial Ua Tau Zoo Tshaj Plaws Ntawm Lub Pituitary Gland Los Tso Cov Hniav Loj Hlob

GHRP-2 5mg/bottle core introduction

Kev loj hlob hormone tso peptide-2|Kev loj hlob hormone secretagogue 5mg / lub raj mis

Lub npe: Loj hlob hormone tso peptide-2

English npeGHRP-2 (Growth Hormone Releasing Peptide-2)

Ib ntus: D-Ala-D- Nal-Ala-Trp-D-Ph-Lys-NH2

Molecular hnyav: kwv yees 817.0 Da

Purity: Ntau dua lossis sib npaug li 98.0% (HPLC)

Cov ntsiab lus: 5mg / lub raj mis

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: Txias ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab cia

GHRP-2 (Growth Hormone Releasing Peptide-2):

GHRP-2 yog ib qho khoom siv hluavtaws tsim, xaiv kev loj hlob hormone- zais cov tshuaj hormones (GH-CSH) uas muaj txiaj ntsig zoo txhawb lub caj pas pituitary kom tso tawm cov tshuaj endogenous los ntawm tshwj xeeb ua rau GH-CSH receptor (GHS-R). Piv rau GHRP-6, GHRP-2 muaj ntau dua receptor affinity, muaj zog GH-CSH-}tso tawm potency, thiab ib nrab ntawm lub neej ntev, yog li tso cai rau kom muaj kev ruaj ntseg thiab ruaj khov pulsatile GH-secreting hauv cov qauv sim. Hauv kev tshawb nrhiav lub cev qoj ib ce, GHRP-2 yog cov cuab yeej tsim qauv rau kev kawm txog cov teebmeem anabolic ntawm kev loj hlob hormone thiab tshuaj xyuas nws cov kev cuam tshuam ntawm cov leeg nqaij protein synthesis, lipid oxidation, thiab tom qab kev cob qhia rov qab.

Hauv kev tshawb fawb txog kev ua kis las, GHRP-2 tau siv dav los ntsuas cov txheej txheem muaj peev xwm los ntawm kev loj hlob hormone txhawb nqa lub cev hnyav nce, txhim kho lub cev muaj pes tsawg leeg, txhim kho kev ua kis las, thiab ua kom nrawm dua tom qab- kev cob qhia rov qab vim tias nws tuaj yeem ua rau cov qib endogenous loj hlob tuaj. Nws muab cov qauv kev sim tswj tau los tshawb txog lub luag haujlwm ntawm lub cev ntawm kev loj hlob hormone hauv kev cob qhia lub zog, kev ua kom muaj zog, thiab cov txheej txheem tiv thaiv catabolic.

GHRP-2 Daim Ntawv Thov:

Raws li lub zog muaj zog thiab xaiv qhov kev loj hlob hormone secretagogue, GHRP-2 feem ntau yog siv los kawm txog kev tso tawm kinetics ntawm endogenous txoj kev loj hlob hormone thiab nws cov kev tswj cov teebmeem ntawm cov leeg nqaij protein synthesis, lipolysis, thiab tom qab kev tawm dag zog cov ntaub so ntswg. Nws yog ib qho kev sim tseem ceeb rau kev tshawb xyuas lub luag haujlwm ntawm kev loj hlob hormone hauv kev txhawb nqa cov leeg nqaij hypertrophy, txhim kho lub zog, txhim kho lub cev muaj pes tsawg leeg (ua kom cov leeg nqaij thiab txo cov rog), thiab ua kom rov zoo dua.

Nws yog siv rau kev tshawb fawb txog kev tshawb fawb txog cov nqaij leeg anabolic metabolism, tiv thaiv- kev sim catabolism, kev soj ntsuam ntawm kev ua kis las kev ua tau zoo dua qub, tom qab- kev ntsuas kev rov qab los, thiab kev txhim kho lub cev, muab cov qauv kev sim ua pov thawj kom raug ntsuas qhov tseeb ntawm lub cev muaj txiaj ntsig ntawm kev loj hlob hormone hauv kev ua kom zoo dua kev tawm dag zog.

Kev siv thiab kev khaws cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Nyiam cov kuab tshuaj: sterile dej rau kev txhaj tshuaj

Carrier solution:diluted nrogsterile physiological saline rau hauv vivo kev tshawb fawb.

Lus ceeb toom: Tsis txhob siv cov kua qaub los yog muaj zog alkali daws. Qhov zoo tshaj plaws stability yog tiav nyob rau hauv nruab nrab rau me ntsis acidic tej yam kev mob.

Tus txheej txheem npaj:

Solvent npaj:

Siv cov dej tsis huv rau kev txhaj tshuaj uas tau lim aseptically los ntawm 0.22 μm lim membrane.

Qhov ntsuas kub hnyav tau rov qab los rau hauv chav sov (20-25 degree).

Reconstitution txheej txheem:

Ntxiv 1.0-2.0 mL dej sterile rau txhaj rau 5 mg vial.

Ncuav maj mam raws lub raj mis phab ntsa kom tsis txhob cuam tshuam ncaj qha rau cov hmoov.

Maj mam tig lub vial rau 3-5 feeb kom txog thaum yaj tag thiab cov tshuaj ua kom meej.

Feem ntau cov ntsiab lus kawg: 5 mg / mL lossis 2.5 mg / mL.

Dispensing thiab dilution:

Tam sim ntawd muab tso rau hauv ib zaug - siv koob tshuaj 20-50 μL siv cov tshuaj qis qis qis.

Dilute nrog sterile saline mus rau qhov yuav tsum tau ua hauj lwm concentration.

Kom meej meej daim ntawv lo: lub npe, concentration, npaj hnub, batch naj npawb, thiab cia tej yam kev mob.

Ua hauj lwm concentration/dosage reference:

Kev sim hauv vitro cell: Qhov feem ntau siv concentration ntau yog 0.1 nM mus rau 1 μM, thiab cov kev sim ua ntej yuav tsum tau ua kom zoo dua qhov concentration raws li hom cell tshwj xeeb thiab lub hom phiaj kev sim.

Tsiaj sim:

Kev txhaj tshuaj subcutaneous: Qhov ntau npaum li cas yog 1 txog 10 ug / kg, ib zaug lossis ob zaug ib hnub.

Kev txhaj tshuaj intramuscular: Yuav siv tau rau cov leeg nqaij hauv zos; ntau npaum li cas yuav tsum tau optimized raws li kev sim ua qauv.

Nws raug pom zootias cov koob tshuaj raug txiav txim siab raws li kev sim ua ntej, cov kev qhia tshwj xeeb ntawm kev tswj hwm, hom tsiaj, thiab cov ntaub ntawv luam tawm.

Piv txwv ntawm kev npaj xam: Yog tias xav tau 100 ug / mL cov tshuaj ua haujlwm, noj 0.02 mL ntawm cov tshuaj hauv Tshuag (5 mg / mL) thiab ntxiv rau 0.98 mL ntawm physiological saline.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Dissolve maj mam: Tsis txhob swirling lossis ua nruj ua tsiv; yooj yim tig maj mam kom yaj.

Cov txheej txheem nruj aseptic: Ua haujlwm hauv lub rooj zaum huv si thiab siv cov khoom siv tsis muaj menyuam, tshwj xeeb tshaj yog thaum siv tshuaj hauv vivo.

Kom tsis txhob muaj teeb pom kev zoo: Nws yog rhiab rau lub teeb, thiab tag nrho cov kauj ruam yuav tsum tau ua nyob rau hauv lub teeb - tiv thaiv tej yam kev mob.

Npaj thiab siv tam sim ntawd: Qhov kev ruaj ntseg yog txwv tom qab hloov kho, yog li nws raug pom zoo kom siv nws sai li sai tau. Tom qab rov ntim dua, khaws cia rau hauv cov xwm txheej tshwj xeeb.

Kom tsis txhob adsorption: dilution nrog cov tshuaj uas muaj 0.1% bovine serum albumin los yog silanized qis-cov hlab adsorption tuaj yeem txo cov adsorption ntawm phab ntsa ntawm lub raj.

2. Cia tej yam kev mob:

Unreconstituted lyophilized hmoov:

Ntev - lub sij hawm cia: khov ntawm -20 degree, txee lub neej 24 lub hlis.

Kev cia zoo: -80℃tob khov, txee lub neej 36 lub hlis.

Kev tiv thaiv nruj ntawm lub teeb: Yuav tsum muab khaws cia rau hauv lub teeb qub -cov ntaub ntawv pov thawj aluminium foil hnab.

Kev tiv thaiv noo noo: Khaws qhuav; muaj desiccant.

Reconstituted daws:

Siv tam sim ntawd: Rau kev ua haujlwm zoo tshaj plaws, siv tam sim tom qab hloov kho.

Short - lub sij hawm cia: Txias ntawm 2-8℃deb ntawm lub teeb, tsis pub ntau tshaj 24 teev.

Repackage thiab khov: Khaws ntawm -20℃lossis -80℃deb ntawm lub teeb tsis pub ntau tshaj 1 lub lis piam.

Rov qab khov-thaw cycles raug txwv nruj heev: qhov siab tshaj plaws ntawm ib qho khov -thaw voj voog.

Kev thauj mus los:

Txias- cov hmoov qhuav: thauj los ntawm cov dej khov qhuav (-78 degree).

Luv - lub sij hawm shipping: 2-8℃ice pob shipping, xyuas kom tus me nyuam tsis pub dhau 48 teev.

Ntim: Lub teeb- pov thawj aluminium foil hnab + lub tshuab nqus tsev foob + ua npuas ncauj insulated lub thawv.

3. Kev ruaj ntseg thiab cov qauv ua tiav:

Tshuaj thiab lub cev stability:

Nws yog qhov ruaj khov nyob rau hauv tsis muaj zog acidic aqueous daws.

Tsis txhob sib cuag nrog cov kua qaub uas muaj zog, muaj zog alkalis, thiab oxidizing tus neeg sawv cev.

Nws yog rhiab heev rau qhov kub thiab txias thiab mechanical stress.

Kev kho ntawm bioactivity:

Kev xa tawm kom raug thiab khaws cia ntawm -80℃yog qhov tseem ceeb rau kev tswj hwm kev ua haujlwm mus ntev.

Thaw thiab muab cov kua dej maj mam tso rau hauv dej khov los yog hauv tub yees ua ntej siv.

Xav taudab tsi, thov hu raupeb

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