GHRP-2 10mg/vial Ua Tau Zoo Tshaj Plaws Ntawm Lub Pituitary Gland Los Tso Cov Hniav Loj Hlob

GHRP-2 10mg/bottle core introduction

Kev loj hlob hormone tso peptide-2|Kev loj hlob hormone secretagogue 10mg / lub raj mis

Lub npe: Loj hlob hormone tso peptide-2

English npeGHRP-2 (Growth Hormone Releasing Peptide-2)

Ib ntus: D-Ala-D- Nal-Ala-Trp-D-Ph-Lys-NH2

Molecular hnyav: kwv yees 817.0 Da

Purity: Ntau dua lossis sib npaug li 98.0% (HPLC)

Cov ntsiab lus: 10mg / lub raj mis

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: khov ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab cia

GHRP-2 (Growth Hormone Releasing Peptide-2):

GHRP-2 yog ib qho kev loj hlob hormone secretagogue uas muaj txiaj ntsig zoo txhawb lub caj pas pituitary kom tso cov tshuaj endogenous loj hlob los ntawm kev xaiv ua kom muaj kev loj hlob hormone secretagogue receptors. Piv nrog rau GHRP-6, GHRP-2 muaj cov qauv kev ua kom zoo, nthuav tawm cov neeg muaj zog affinity thiab lub sij hawm ntev ntawm kev ua, ua kom pom kev loj hlob hormone tso tawm ntau dua hauv kev sim. Hauv kev tshawb fawb txog lub cev qoj ib ce, GHRP-2 nquag siv los ntsuas lub luag haujlwm ntawm kev loj hlob hormone endogenous ntawm cov leeg nqaij anabolism.

Vim nws lub zog loj hlob hormone tso tawm lub peev xwm, GHRP-2 yog qhov tseem ceeb hauv kev kawm txog cov txiaj ntsig ntawm kev loj hlob hormone ntawm cov leeg nqaij protein synthesis, lipolysis, thiab kev tawm dag zog rov qab. GHRP-2 tuaj yeem ua tus qauv kev sim cov cuab yeej los pab cov kws tshawb fawb tshawb nrhiav lub luag haujlwm ntawm cov tshuaj hormones loj hlob hauv kev txhim kho kev ua kis las thaum soj ntsuam cov txheej txheem los ntawm kev loj hlob hormone pab txhawb kev txhawb zog kev hloov pauv, cov leeg nqaij hypertrophy, thiab kev txhim kho lub cev.

GHRP-2 Daim Ntawv Thov:

Raws li kev loj hlob hormone secretagogue, feem ntau yog siv los kawm txog nws cov teebmeem ntawm pulsatile txoj kev loj hlob hormone secretion thiab tshuaj xyuas nws lub luag haujlwm tswj hauv cov leeg nqaij protein synthesis tus nqi, lipid oxidation efficiency, thiab tom qab- qoj ib ce rov qab hauv cov qauv sim. Nws yog ib qho cuab yeej tseem ceeb hauv kev tshawb nrhiav cov metabolism hauv kev tawm dag zog thiab tshawb nrhiav cov leeg nqaij hloov kho cov txheej txheem.

Nws yog siv rau kev sim physiology kev sim, tiv thaiv - kev tshawb fawb catabolism, kev tshuaj xyuas ntawm cov leeg nqaij hypertrophy mechanisms, thiab kev tshawb fawb txog kev txhim kho lub cev muaj pes tsawg leeg, muab cov kev tshawb fawb txhim khu kev qha rau kev ntsuas lub cev muaj txiaj ntsig ntawm kev loj hlob hormone hauv cov txheej txheem ntawm kev tawm dag zog raws li kev tswj hwm nruj.

Kev siv thiab kev khaws cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Nyiam cov kuab tshuaj: sterile dej rau kev txhaj tshuaj

Carrier solution:diluted nrogsterile physiological saline rau hauv vivo kev tshawb fawb.

Lus ceeb toom: Tsis txhob siv cov kua qaub los yog muaj zog alkali daws. Stability yog pom zoo nyob rau hauv nruab nrab tej yam kev mob.

Tus txheej txheem npaj:

Solvent npaj:

Siv cov dej tsis huv rau kev txhaj tshuaj uas tau lim aseptically los ntawm 0.22 μm lim membrane.

Qhov ntsuas kub hnyav tau rov qab los rau hauv chav sov (20-25 degree).

Reconstitution txheej txheem:

Ntxiv 1.0 mL dej sterile rau txhaj rau 10 mg vial.

Ncuav maj mam raws lub raj mis phab ntsa kom tsis txhob cuam tshuam ncaj qha rau cov hmoov.

Maj mam tig lub vial rau 3-5 feeb kom txog thaum yaj tag thiab cov tshuaj ua kom meej.

Qhov kawg concentration: 10 mg / mL.

Dispensing thiab dilution:

Tam sim ntawd muab tso rau hauv ib zaug - siv koob tshuaj 20-50 μL siv cov tshuaj qis qis qis.

Dilute nrog sterile saline mus rau qhov yuav tsum tau ua hauj lwm concentration.

Kom meej meej daim ntawv lo: lub npe, concentration, npaj hnub, batch naj npawb, thiab cia tej yam kev mob.

Ua hauj lwm concentration/dosage reference:

Kev sim hauv vitro: Qhov feem ntau siv concentration ntau yog 0.1 nM mus rau 1 μM, thiab cov kev sim ua ntej yuav tsum tau ua kom zoo dua qhov concentration raws li qhov kev sim tshwj xeeb.

Tsiaj sim:

Kev txhaj tshuaj subcutaneous: Qhov ntau npaum li cas yog 1 txog 10 ug / kg.

Nws raug pom zootias cov koob tshuaj meej meej raug txiav txim raws li tus qauv tsiaj tshwj xeeb, txoj hauv kev ntawm kev tswj hwm, cov hom phiaj tshawb fawb, thiab cov ntaub ntawv luam tawm.

Piv txwv ntawm kev npaj xam: Yog tias xav tau 100 ug / mL cov tshuaj ua haujlwm, noj 0.01 mL ntawm cov tshuaj hauv Tshuag thiab ntxiv rau 0.99 mL ntawm physiological saline.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Cov txheej txheem nruj aseptic: Ua haujlwm hauv lub rooj zaum huv si thiab siv cov khoom siv tsis muaj menyuam, tshwj xeeb tshaj yog thaum siv tshuaj hauv vivo.

Zam lub teeb: Nws yog rhiab heev rau lub teeb, yog li nws raug pom zoo kom ua haujlwm hauv qhov chaw tsaus.

Npaj thiab siv tam sim ntawd: Tom qab kev kho dua tshiab, nws yuav tsum siv li ntawm 24 teev. Tom qab muab tshuaj, cia nyob rau hauv cov kev cai teev tseg.

Tsis txhob adsorption: Siv silanized qis- cov raj adsorption tuaj yeem txo cov adsorption poob ntawm phab ntsa raj.

2. Cia tej yam kev mob:

Unreconstituted lyophilized hmoov:

Ntev - lub sij hawm cia: khov ntawm -20 degree, txee lub neej 24 lub hlis.

Kev cia zoo: -80℃tob khov, txee lub neej 36 lub hlis.

Kev tiv thaiv nruj ntawm lub teeb: Yuav tsum muab khaws cia rau hauv lub teeb qub- pov thawj aluminium foil hnab.

Kev tiv thaiv noo noo: Khaws qhuav; muaj desiccant.

Reconstituted daws:

Siv tam sim ntawd: Rau kev ua haujlwm zoo tshaj plaws, siv tam sim tom qab hloov kho.

Short - lub sij hawm cia: Txias ntawm 2-8℃deb ntawm lub teeb, tsis pub ntau tshaj 24 teev.

Repackage thiab khov: Khaws ntawm -20℃lossis -80℃deb ntawm lub teeb tsis pub ntau tshaj 72 teev.

Rov qab khov-thaw cycles raug txwv nruj heev: qhov siab tshaj plaws ntawm ib qho khov -thaw voj voog.

Kev thauj mus los:

Txias- cov hmoov qhuav: thauj los ntawm cov dej khov qhuav (-78 degree).

Luv - lub sij hawm shipping: 2-8℃ice pob shipping, xyuas kom tus me nyuam tsis pub dhau 48 teev.

3. Kev ruaj ntseg thiab cov qauv ua tiav:

Tshuaj thiab lub cev stability:

Nws yog qhov ruaj khov hauv nruab nrab pH aqueous daws.

Tsis txhob sib cuag nrog cov kua qaub uas muaj zog, muaj zog alkalis, thiab oxidizing tus neeg sawv cev.

Nws yog rhiab heev rau qhov kub thiab txias, yog li tsis tshua muaj - qhov kub thiab txias cia tau pom zoo.

Kev kho ntawm bioactivity:

Kev khaws cia kom zoo thiab cov txheej txheem npaj tsim nyog yog qhov tseem ceeb rau kev tuav haujlwm.

Txhawm rau kom tsis txhob rov khov dua -thaw cycles, nws raug nquahu kom khaws cov ntsiab lus hauv qhov me me.

Xav taudab tsi, thov hu raupeb

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