Liraglutide 5mg / vial Tuam Tshoj Peptides Freeze-Powder qhuav

Liraglutide5mg / lub raj mis kev taw qhia

Pharmaceutical -qib peptide formulation |Liraglutide5mg / vial, ua nyob rau hauv Suav teb

Specifications5mg / lub raj mis, 5 fwj / lub thawv

Purity: Ntau dua lossis sib npaug li 99% (HPLC kuaj pom)

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: Txias ntawm 2-8 degree, tiv thaiv los ntawm lub teeb. Siv nyob rau hauv 28 hnub tom qab reconstitution.

Cov tshuaj liraglutidecore zoo thiab functions

Liraglutide yog ibntev - ua haujlwm GLP-1 receptor agonistuasmimics cov teebmeem ntawm lub cev lub ntuj GLP-1 cov tshuaj hormones.Nws muaj cov ntawv thov tseem ceeb hauvKev tswj qhov hnyav, kev tswj ntshav qabzib, thiab kev noj qab haus huv ntawm cov hlab plawv, thiab yog ib qho kev txiav- cov cuab yeej cuab tam hauv kev tshawb fawb metabolic tam sim no.

✅ Ntau-lub hom phiaj kev tswj hwm txoj cai:

Tswj kev qab los noj mov: Ua rau lub qab los noj mov qhov chaw nyob rau hauv lub hypothalamus, ua kom lub siab puv thiab txo calorie kom tsawg.

Kev tswj lub plab zom mov: slows tus nqi ntawm lub plab khoob thiab prolongs lub sij hawm ntawm satiety.

Insulin stimulation: Glucose-nyob ntawm cov tshuaj insulin pab tswj cov ntshav qab zib kom ruaj khov.

Glucagon inhibition: inhibits glucagon secretion thiab txo cov piam thaj hauv siab.

Kev tiv thaiv plawv: Kev tshawb fawb tau pom tias nws muaj peev xwm tiv thaiv kab mob plawv.

✅Qualityqhov zoo ntawm Suav manufacturers:

Qhia meej meej: Siv cov poov xab siab heev / E. coli qhia system, siab - cov khoom purity tau txais.

Kev hloov kho nyuaj: Mastering fatty acid side chain modification technology kom paub meej qhov tseeb spatial qauv thiab bioactivity ntawm cov khoom.

Kev ua kom huv huv: Ntau- cov txheej txheem chromatography purification (ion exchange, hydrophobicity, gel filtration) kom tshem tawm cov khoom noj protein thiab impurities.

Kev ua validation: Nyob rau hauv vitro cell kev soj ntsuam thiab nyob rau hauv vivo pharmacodynamic validations yog ua nyob rau hauv txhua batch.

Aseptic ntau lawm: Aseptic filling thiab khov - ziab yog ua tiav nyob rau hauv chav kawm B + A huv si.

✅ khoomNta:

Ntev -ntev nyhuv: Ib nrab - lub neej yog kwv yees li 13 teev, tso cai rau ib zaug - noj txhua hnub.

Cov ntshav qab zib ua kom zoo heev: Zoo tswj kev yoo mov thiab postprandial ntshav qab zib.

Clear yuag poob: Kev tswj qhov hnyav los ntawm ntau lub hauv nruab nrab thiab peripheral mechanisms.

Zoo kev nyab xeeb profile: Tsis tshua muaj kev pheej hmoo ntawm hypoglycemia

LiraglutideDaim ntawv qhia kev siv thiab cia

1. Kev kho dua tshiab:

Kev xaiv cov kuab tshuaj: Cov kuab tshuaj tshwj xeeb tsim los siv nrog cov tshuaj(cov dej tsis muaj menyuam rau kev txhaj tshuaj lossis lwm yam tshuaj tsis haum) yuav tsum tau siv.

Txuj kev npaj: Txhajcov chaw tsim khoom- hais txog ntimntawm sterile hnyav rau hauv 5mg hmoov vial.

Cov txheej txheem dissolving: Maj mam tiglub raj mis kom yaj tag nrho cov hmoov;tsis txhob tshee hnyo.

Concentration kev pom zoo: Lub concentration tom qab reconstitution yog5 mg/ml(thov ua raws li cov lus qhia ntawm lub pob ntxig rau lub ntim tshwj xeeb).

2. Cia tej yam kev mob:

Tsis qhib: Khaws ntawm 2-8℃mus txog 24 lub hlis.Tsis txhob khov.

Reconstituted: tuaj yeem khaws cia rau 28 hnubntawm 2-8 degree. Nws raug nquahu kom sau lub raj mis nrog hnub qhib.

Kev thauj mus los: Kev thauj mus los txias thoob plaws (2-8 degree), siv lub thawv tshwj xeeb insulated.

Lus Cim Tseem Ceeb: Tsis txhob raug lub teeb.Cov tshuaj reconstituted yuav tsum ntshiab thiab tsis muaj xim. Tsis txhob siv yog tias nws yog huab lossis muaj cov khoom.

3. Txuj kev kawm noj tshuaj noj:

Txoj kev tswj hwm: Kev txhaj tshuaj subcutaneous hauv plab, ncej puab, lossis sab caj npab(tsis txhob siv tshuaj intravenously lossis intramuscularly).

Pib koob tshuaj: 0.6 mg / hnub, tsawg kawg 1 lub lis piam.

Dosage escalation: Nce 0.6 mg txhua lub lim tiam kom txog thaum lub hom phiaj koob tshuaj.

Kho koob tshuaj: 1.2 mg / hnub lossis 1.8 mg / hnub (nyob ntawm kev tsim qauv)

Lub sijhawm txhaj tshuaj: Ib hnub ib zaug ntawmib lub sij hawm ruaj(ua ntej lossis tom qab noj mov, tsis hais lub sijhawm noj mov).

Txhaj chaw rotation: Qhov chaw txhaj tshuaj yuav tsum tau hloov pauv rau txhua qhov kev txhaj tshuaj kom txo qis cov tshuaj tiv thaiv hauv zos.

4. Piv txwv kev noj tshuaj thiab kev npaj:

Lub hom phiaj koob tshuaj 1.2 mg / hnub: Kos 0.24 ml(240 ul) ntawm cov tshuaj reconstituted.

Lub hom phiaj koob tshuaj 1.8 mg / hnub: Kos 0.36 ml(360 ul) ntawm cov tshuaj reconstituted.

Cov cuab yeej siv: Nws raug pom zoo kom sivib qho tshuaj insulinlos yogib tug tshwj xeeb cwj mem injectorlos xyuas kom meej qhov koob tshuaj.

Vim li cas xaivLiraglutide ua nyob rau hauv Suav teb?

Siabtechnical pib: Mastering ua tiav fermentation, hloov kho, thiab purification technologies rau ntev -ua yeeb yam GLP-1 analogs

Zoobenchmarked tawm tsam thoob ntiaj teb cov qauv: Cov txheej txheem ntau lawm thiab cov qauv zoo nruj me ntsis ua raws li cov chaw muag tshuaj thoob ntiaj teb.

Qhov tseem ceebtus nqi kom zoo dua: Loj -scale bioreactor ntau lawm txo cov nqi tsev.

Ua kom tiavCov ntaub ntawv System: Peb tuaj yeem muab cov neeg siv khoom nrog tag nrho cov ntaub ntawv CMC uas ua tau raws li kev sau npe thoob ntiaj teb.

ruaj khovsaw hlau: Xaus-rau- kawg tswj los ntawm plasmid mus rau cov khoom tiav ua kom muaj kev ruaj ntseg.

Cov ntsiab lus

Cov khoom no sawv cevTuam Tshoj qib siab hauv kev tshawb fawb thiab kev tsim cov tshuaj lom neeg lom neeg. Los ntawmadvanced bioexpression technology, kev tswj cov txheej txheem nruj, thiab kev tswj xyuas zoo, peb muabsiab -zoo, muaj zog heev liraglutide kev tshawb fawb cov khoom siv rau cov chaw tshawb fawb thoob ntiaj teb. Nwszoo-txhais txheej txheem ntawm kev nqis tes ua thiab kev tshawb fawb dav davua nwsib qho cuab yeej tseem ceeb rau kev kawm txog cov kab mob metabolic thiab ntau yam kab mob.

Xav taudab tsi, thov hu raupeb

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