CJC1295 Tsis muaj DAC 2mg / vial Ua kom cov leeg nqaij, txhim kho lub zog thiab kev ua kis las

CJC-1295 (tsis muaj DAC) 2mg / vial core qhia

Kev loj hlob hormone- tso cov tshuaj hormones analogues|Kev loj hlob hormone- tso peptide 2mg / vial

Lub npe: CJC-1295 (Drug-free affinity complex)

English npe: CJC-1295 (tsis muaj DAC)

Ib ntus: Hloov kho GRF(1-29)

Molecular hnyav: kwv yees 3367.8 Da

Purity: Ntau dua lossis sib npaug li 98.0% (HPLC)

Cov ntsiab lus: 2mg / lub raj mis

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: Txias ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab cia

CJC-1295 (tsis muaj DAC) kev loj hlob hormone-tso cov tshuaj hormone analog:

CJC-1295 (DAC-dawb) yog ib qho kev hloov pauv loj hlob hormone- tso tawm cov tshuaj hormone (GHRH) analog muaj li ntawm 29 amino acids, nrog cov qauv zoo ib yam li endogenous GHRH. Tsis zoo li qhov ntev - ua yeeb yam uas muaj DAC, DAC - dawb version muaj luv dua ib nrab- lub neej, txhawb lub caj pas pituitary kom tso tawm cov tshuaj endogenous loj hlob zoo dua rau nws lub cev lub cev zoo. Hauv kev sim kev tshawb fawb, CJC-1295 (DAC-dawb) tau pom muaj peev xwm ua tau zoo dua los ua cov qauv pulsatile secretion ntawm tib neeg txoj kev loj hlob hormone, ua rau nws yog ib qho cuab yeej tshawb fawb zoo tshaj plaws rau kev kawm txog lub cev tso tawm suab ntawm kev loj hlob hormone thiab ntsuas nws lub luag haujlwm hauv cov leeg nqaij synthesis thiab lipid metabolism.

Hauv kev tawm dag zog lub cev thiab kev tshawb fawb ntawm cov leeg nqaij metabolism, CJC-1295 (tsis muaj DAC) tau nyiam vim nws muaj peev xwm ua rau muaj kev loj hlob hormone tso tawm qauv uas zoo ib yam li lub cev lub cev. Cov kws tshawb fawb tau siv nws hauv cov qauv tsiaj thiab cov kev sim ntawm tes los kawm txog kev tso tawm kinetics ntawm endogenous txoj kev loj hlob hormone thiab nws cov txheej txheem tshwj xeeb hauv kev txhawb nqa cov protein synthesis, nce lean lub cev loj, txhawb lipolysis, thiab txhim kho kev rov qab ua haujlwm rov qab, muab pov thawj tshawb fawb rau kev nkag siab lub luag haujlwm ntawm kev loj hlob hormone hauv kev tawm dag zog thiab lub cev muaj pes tsawg leeg optimization.

CJC-1295 (tsis muaj DAC) Daim Ntawv Thov:

Raws li luv luv - ua yeeb yam loj hlob hormone- tso tawm cov tshuaj hormone analog, feem ntau yog siv los kawm txog cov kev cai ntawm pulsatile loj hlob hormone secretion thiab los ntsuas nws cov kev tswj xyuas ntawm cov leeg nqaij protein synthesis tus nqi, lipid oxidation efficiency, leeg satellite cell activation, thiab tag nrho lub zog metabolism hauv kev sim ua qauv. Nws yog ib qho tseem ceeb ntawm kev sim cov cuab yeej rau kev kawm lub physiological rhythms ntawm kev loj hlob hormone thiab nws lub luag hauj lwm nyob rau hauv kev tawm dag zog, kho cov leeg, thiab kev txhim kho lub cev muaj pes tsawg leeg.

Nws yog siv rau hauv kev tshawb fawb txog kev tawm dag zog lub cev, kev sim cov leeg nqaij metabolism, kev tsom xam anabolism mechanism, tiv thaiv - kev tshawb fawb txog kev laus, thiab kev loj hlob hormone secretion atherosclerosis. Nws yog siv los kawm txog qhov muaj feem cuam tshuam ntawm luv luv - ua yeeb yam GHRH analogs ntawm kev txhawb nqa cov leeg kev loj hlob, txo cov rog hauv lub cev, txhim kho kev ua kis las, thiab ua kom cov txheej txheem rov qab los raws li kev sim tswj nruj heev.

Kev siv thiab kev khaws cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Nyiam cov kuab tshuaj: sterile dej rau kev txhaj tshuaj

Carrier solution:diluted nrogsterile physiological saline rau hauv vivo kev tshawb fawb.

Lus ceeb toom: Nws muaj qhov ruaj khov zoo tshaj plaws hauv nruab nrab tsis haum tshuaj (pH 7.2-7.6). Tsis txhob siv cov kua qaub uas muaj zog lossis muaj zog hauv paus daws teeb meem.

Tus txheej txheem npaj:

Solvent npaj:

Siv cov dej tsis huv rau kev txhaj tshuaj uas tau lim aseptically los ntawm 0.22 μm lim membrane.

Qhov ntsuas kub hnyav tau rov qab los rau hauv chav sov (20-25 degree).

Reconstitution txheej txheem:

Ntxiv 1.0-2.0 mL dej sterile rau txhaj rau 2 mg vial.

Ncuav maj mam raws lub raj mis phab ntsa kom tsis txhob cuam tshuam ncaj qha rau cov hmoov.

Maj mam tig lub vial rau 3-5 feeb kom txog thaum yaj tag thiab cov tshuaj ua kom meej.

Feem ntau cov ntsiab lus kawg: 2 mg / mL lossis 1 mg / mL.

Dispensing thiab dilution:

Tam sim ntawd muab tso rau hauv ib zaug - siv koob tshuaj 20-50 μL siv cov tshuaj qis qis qis.

Dilute nrog sterile saline mus rau qhov yuav tsum tau ua hauj lwm concentration.

Kom meej meej daim ntawv lo: lub npe, concentration, npaj hnub, batch naj npawb, thiab cia tej yam kev mob.

Ua hauj lwm concentration/dosage reference:

Kev sim hauv vitro cell: Qhov feem ntau siv cov concentration ntau yog 0.1 nM txog 100 nM, thiab cov kev sim ua ntej yuav tsum tau ua kom zoo dua qhov concentration raws li hom cell tshwj xeeb thiab lub hom phiaj kev sim.

Tsiaj sim:

Kev txhaj tshuaj subcutaneous: Qhov ntau npaum li cas yog 1 txog 5 ug / kg, thiab qhov zaus ntawm kev tswj hwm tau txiav txim siab raws li kev tshawb fawb lub hom phiaj.

Nws raug pom zootias qhov kev noj tshuaj thiab kev noj tshuaj kom raug raug txiav txim raws li tus qauv tsiaj tshwj xeeb, txoj hauv kev ntawm kev tswj hwm, cov hom phiaj tshawb fawb, thiab cov ntaub ntawv luam tawm.

Piv txwv ntawm kev npaj xam: Yog tias xav tau 100 ug / mL cov tshuaj ua haujlwm, noj 0.05 mL ntawm cov tshuaj hauv Tshuag (2 mg / mL) thiab ntxiv rau 0.95 mL ntawm physiological saline.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Dissolve maj mam: Tsis txhob swirling lossis ua nruj ua tsiv; yooj yim tig maj mam kom yaj.

Cov txheej txheem nruj aseptic: Ua haujlwm hauv lub rooj zaum huv si thiab siv cov khoom siv tsis muaj menyuam, tshwj xeeb tshaj yog thaum siv tshuaj hauv vivo.

Kom tsis txhob muaj teeb pom kev zoo: Nws yog rhiab rau lub teeb, thiab tag nrho cov kauj ruam yuav tsum tau ua nyob rau hauv lub teeb - tiv thaiv tej yam kev mob.

Npaj thiab siv tam sim ntawd: Qhov kev ruaj ntseg yog txwv tom qab hloov kho, yog li nws raug pom zoo kom siv nws sai li sai tau. Tom qab rov ntim dua, khaws cia rau hauv cov xwm txheej tshwj xeeb.

Kom tsis txhob adsorption: dilution nrog cov tshuaj uas muaj 0.1% bovine serum albumin los yog silanized qis-cov hlab adsorption tuaj yeem txo cov adsorption ntawm phab ntsa raj.

2. Cia tej yam kev mob:

Unreconstituted lyophilized hmoov:

Ntev - lub sij hawm cia: khov ntawm -20 degree, txee lub neej 24 lub hlis.

Kev cia zoo: -80℃tob khov, txee lub neej 36 lub hlis.

Kev tiv thaiv nruj ntawm lub teeb: Yuav tsum muab khaws cia rau hauv lub teeb qub- pov thawj aluminium foil hnab.

Kev tiv thaiv noo noo: Khaws qhuav; muaj desiccant.

Reconstituted daws:

Siv tam sim ntawd: Rau kev ua haujlwm zoo tshaj plaws, siv tam sim tom qab hloov kho.

Short - lub sij hawm cia: Txias ntawm 2-8℃deb ntawm lub teeb, tsis pub ntau tshaj 24 teev.

Repackage thiab khov: Khaws ntawm -20℃lossis -80℃deb ntawm lub teeb tsis pub ntau tshaj 1 lub lis piam.

Rov qab khov-thaw cycles raug txwv nruj heev: qhov siab tshaj plaws ntawm ib qho khov -thaw voj voog.

Kev thauj mus los:

Txias- cov hmoov qhuav: thauj los ntawm cov dej khov qhuav (-78 degree).

Luv - lub sij hawm shipping: 2-8℃ice pob shipping, xyuas kom tus me nyuam tsis pub dhau 48 teev.

Ntim: Lub teeb- pov thawj aluminium foil hnab + lub tshuab nqus tsev foob + ua npuas ncauj insulated lub thawv.

3. Kev ruaj ntseg thiab cov qauv ua tiav:

Tshuaj thiab lub cev stability:

Nws yog qhov ruaj khov nyob rau hauv nruab nrab pH aqueous daws thiab tsis daws teeb meem.

Tsis txhob sib cuag nrog cov kua qaub uas muaj zog, muaj zog alkalis, thiab oxidizing tus neeg sawv cev.

Nws yog rhiab heev rau qhov kub thiab txias thiab mechanical stress.

Kev kho ntawm bioactivity:

Kev xa tawm kom raug thiab khaws cia ntawm -80℃yog qhov tseem ceeb rau kev tswj xyuas kev ua haujlwm mus ntev.

Thaw thiab muab cov kua dej maj mam tso rau hauv dej khov los yog hauv tub yees ua ntej siv.

Xav taudab tsi, thov hu raupeb

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