Hexarelin 2mg / vial core qhia
Kev loj hlob hormone- tso peptide|Kev loj hlob hormone secretagogue 2mg / lub raj mis
Lub npeTom ntej: Hexamethasone
English npe: Hexarelin
Ib ntus: His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
Molecular hnyav: kwv yees 887.0 Da
Purity: Ntau dua lossis sib npaug li 98.0% (HPLC)
Cov ntsiab lus: 2mg / lub raj mis
Qhov tshwm sim: Dawb lyophilized hmoov
Cia: Txias ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.
Daim ntawv qhia kev siv thiab cia
Hexarelin:
Haisorelin yog ib qho hluavtaws hexapeptide kev loj hlob hormone-tso peptide (GHRP) uas yog los ntawm kev loj hlob hormone secretagogue tsev neeg. Nws muaj zog txhawb lub caj pas pituitary kom tso cov tshuaj endogenous loj hlob. Tsis zoo li tej yam ntuj tso kev loj hlob hormone- tso tawm cov tshuaj hormones (GHRH), haisorelin exerts nws cov nyhuv los ntawm activating lub loj hlob hormone secretagogue receptor (GHS-R), uas ua rau muaj ntau dua bioavailability thiab ib nrab neej ntev dua -. Hauv kev sim, haisorelin tau pom tias muaj zog loj hlob hormone- tso tawm cov nyhuv, ua rau nws muaj txiaj ntsig rau kev tshawb fawb txog kev loj hlob hormone axis muaj nuj nqi, protein synthesis thiab metabolism, thiab cov txheej txheem kho cov ntaub so ntswg.
Vim nws lub zog stimulatory nyhuv ntawm kev loj hlob hormone tso tawm, haisaraline tau txais kev saib xyuas thoob plaws hauv kev tawm dag zog lub cev, kev tshawb fawb ntawm cov leeg nqaij, thiab kev tshawb fawb los tiv thaiv- kev laus. Hauv cov qauv kev sim uas xav tau qhov kev ntsuam xyuas ntawm kev loj hlob hormone qhov cuam tshuam rau cov leeg nqaij, cov metabolism hauv rog, kev ua kis las, thiab rov qab los, haisaraline ua haujlwm raws li cov qauv kev tshawb fawb, muab kev sim hauv paus rau kev tshawb nrhiav lub peev xwm ntawm kev loj hlob hormone hauv kev tawm dag zog thiab kev txhim kho lub cev.
Kev siv ntawm Hexarelin:
Raws li lub zog loj hlob hormone secretagogue, nws feem ntau yog siv los kawm nws cov txiaj ntsig stimulatory ntawm kev loj hlob hormone secretion thiab ntsuam xyuas nws cov kev cuam tshuam ntawm protein synthesis, lipolysis, nqaij pawg, thiab kis las ua si hauv kev sim ua qauv. Nws yog ib qho cuab yeej tshawb fawb tseem ceeb rau kev tshawb nrhiav lub luag haujlwm ntawm kev loj hlob hormone hauv kev tawm dag zog, txhim kho lub cev, thiab tiv thaiv - tshawb fawb kev laus.
Nws tau siv rau hauv kev tshawb fawb txog kev tawm dag zog lub cev, kev sim cov leeg nqaij metabolism, tiv thaiv- kev tshawb fawb txog kev laus, thiab kev tshawb nrhiav cov ntaub so ntswg kho. Nws yog siv los kawm txog qhov muaj peev xwm tswj hwm qhov cuam tshuam ntawm kev loj hlob hormone tso tawm ntawm cov leeg kev loj hlob, cov roj metabolism hauv lub cev, thiab tag nrho lub cev muaj pes tsawg leeg nyob rau hauv kev tswj xyuas nruj me ntsis.
Kev siv thiab kev khaws cia
1. Kev kho dua tshiab thiab kev npaj:
Cov kuab tshuaj pom zoo:
Nyiam cov kuab tshuaj: sterile dej rau kev txhaj tshuaj
Carrier solution:diluted nrogsterile physiological saline rau hauv vivo kev tshawb fawb.
Lus ceeb toom: Tsis txhob siv cov kua qaub los yog muaj zog alkali daws. Cov peptide no ruaj khov dua nyob rau hauv nruab nrab tej yam kev mob.
Tus txheej txheem npaj:
Solvent npaj:
Siv cov dej tsis huv rau kev txhaj tshuaj uas tau lim aseptically los ntawm 0.22 μm lim membrane.
Qhov ntsuas kub hnyav tau rov qab los rau hauv chav sov (20-25 degree).
Reconstitution txheej txheem:
Ntxiv 1.0 mL ntawm sterile dej rau txhaj rau 2 mg vial.
Ncuav maj mam raws lub raj mis phab ntsa kom tsis txhob cuam tshuam ncaj qha rau cov hmoov.
Maj mam tig lub vial rau 3-5 feeb kom txog thaum yaj tag thiab cov tshuaj ua kom meej.
Qhov kawg concentration: 2 mg / mL (kwv yees li 2.25 mM).
Dispensing thiab dilution:
Tam sim ntawd muab tso rau hauv ib zaug - siv koob tshuaj 20-50 μL siv cov tshuaj qis qis qis.
Dilute nrog sterile saline mus rau qhov yuav tsum tau ua hauj lwm concentration.
Kom meej meej daim ntawv lo: lub npe, concentration, npaj hnub, batch naj npawb, thiab cia tej yam kev mob.
Ua hauj lwm concentration/dosage reference:
Kev sim hauv vitro: Qhov feem ntau siv concentration ntau yog 0.1 nM mus rau 1 μM, thiab cov kev sim ua ntej yuav tsum tau ua kom zoo dua qhov concentration raws li qhov kev sim tshwj xeeb.
Tsiaj sim:
Kev txhaj tshuaj subcutaneous: Qhov ntau npaum li cas yog 1 txog 10 ug / kg.
Nws raug pom zootias cov koob tshuaj raug txiav txim siab raws li tus qauv tsiaj tshwj xeeb, txoj hauv kev ntawm kev tswj hwm, cov hom phiaj tshawb fawb, thiab cov ntaub ntawv luam tawm.
Piv txwv ntawm kev npaj xam: Yog tias xav tau 100 ug / mL cov tshuaj ua haujlwm, noj 0.05 mL ntawm cov tshuaj hauv Tshuag thiab ntxiv rau 0.95 mL ntawm physiological saline.
Cov ntsiab lus tseem ceeb kom nco ntsoov:
Cov txheej txheem nruj aseptic: Ua haujlwm hauv lub rooj zaum huv si thiab siv cov khoom siv tsis muaj menyuam, tshwj xeeb tshaj yog thaum siv tshuaj hauv vivo.
Zam lub teeb: Nws yog rhiab heev rau lub teeb, yog li nws raug pom zoo kom ua haujlwm hauv qhov chaw tsaus.
Npaj thiab siv tam sim ntawd: Tom qab kev kho dua tshiab, nws yuav tsum siv li ntawm 24 teev. Tom qab dispensing, cia nyob rau hauv raws li tej yam kev mob.
Tsis txhob adsorption: Siv silanized qis- cov raj adsorption tuaj yeem txo qis adsorption poob ntawm phab ntsa raj.
2. Cia tej yam kev mob:
Unreconstituted lyophilized hmoov:
Ntev - lub sij hawm cia: khov ntawm -20 degree, txee lub neej 24 lub hlis.
Kev cia zoo: -80℃tob khov, txee lub neej 36 lub hlis.
Kev tiv thaiv nruj ntawm lub teeb: Yuav tsum muab khaws cia rau hauv lub teeb qub- pov thawj aluminium foil hnab.
Kev tiv thaiv noo noo: Khaws qhuav; muaj desiccant.
Reconstituted daws:
Siv tam sim ntawd: Rau kev ua haujlwm zoo tshaj plaws, siv tam sim tom qab hloov kho.
Short - lub sij hawm cia: Txias ntawm 2-8℃deb ntawm lub teeb, tsis pub ntau tshaj 24 teev.
Repackage thiab khov: Khaws ntawm -20℃lossis -80℃deb ntawm lub teeb tsis pub ntau tshaj 72 teev.
Rov qab khov-thaw cycles raug txwv nruj heev: qhov siab tshaj plaws ntawm ib qho khov -thaw voj voog.
Kev thauj mus los:
Txias- cov hmoov qhuav: thauj los ntawm cov dej khov qhuav (-78 degree).
Luv - lub sij hawm shipping: 2-8℃ice pob shipping, xyuas kom tus me nyuam tsis pub dhau 48 teev.
3. Kev ruaj ntseg thiab cov qauv ua tiav:
Tshuaj thiab lub cev stability:
Nws yog qhov ruaj khov hauv nruab nrab pH aqueous daws.
Tsis txhob sib cuag nrog cov kua qaub uas muaj zog, muaj zog alkalis, thiab oxidizing tus neeg sawv cev.
Nws yog rhiab heev rau qhov kub thiab txias, yog li tsis tshua muaj - qhov kub thiab txias cia tau pom zoo.
Kev kho ntawm bioactivity:
Kev khaws cia kom zoo thiab cov txheej txheem npaj tsim nyog yog qhov tseem ceeb rau kev tuav haujlwm.
Txhawm rau kom tsis txhob rov khov dua -thaw cycles, nws raug nquahu kom khaws cov ntsiab lus hauv qhov me me.
Xav taudab tsi, thov hu raupeb
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Cim npe nrov: hexarelin 2mg / vial nkoos lub cev tus kheej txoj kev loj hlob hormone rau secrete nyob rau hauv pulses, Tuam Tshoj hexarelin 2mg / vial heev nkoos lub cev txoj kev loj hlob hormone rau secrete nyob rau hauv pulses manufacturers, lwm tus neeg, Hoobkas
