Selank 5mg / lub raj mis kev taw qhia
Neuromodulatory heptapeptide|Centrally active peptide 5mg / lub raj mis
Hom npe: Slank
English npe: Selank
Ib ntus: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular hnyav:kwv 751,9d
Purity: Ntau dua lossis sib npaug li 98.5% (HPLC)
Cov ntsiab lus: 5mg / lub raj mis
Qhov tshwm sim: Dawb lyophilized hmoov
Cia: khov ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.
Daim ntawv qhia kev siv thiab cia
Selank:
Slanc yog ib qho hluavtaws heptapeptide, ib qho analogue ntawm endogenous thymopoietin metabolic fragments, nthuav tawm txhim kho enzymatic stability thiab bioavailability. Raws li neuroactive peptide, nws tau pom nyob rau hauv cov qauv kev tshawb fawb los tswj cov kab mob neurotransmitter, suav nrog GABAergic, serotonergic, thiab glutamatergic systems, yog li muaj feem cuam tshuam rau kev ntxhov siab, ntxhov siab -zoo li kev coj cwj pwm, thiab kev paub txog kev ua haujlwm. Piv nrog rau cov tshuaj benzodiazepines ib txwm muaj, nws cov qauv peptide thiab lub peev xwm rau ntau -neurotransmitter kev tswj hwm ua rau nws yog ib qho tseem ceeb ntawm cov cuab yeej siv rau kev kawm cov txheej txheem neurobiological ntsig txog kev ntxhov siab, kev kawm thiab kev nco, thiab kev hloov pauv kev ntxhov siab.
Vim nws lub peev xwm hauv nruab nrab paj hlwb modulatory zog, slanc feem ntau siv los ntawm cov kws tshawb fawb hauv neuroscience, kev coj tus cwj pwm, thiab psychoneuroimmunology. Piv rau qee cov tshuaj uas muaj ib qho kev ua haujlwm thiab zoo-txhais cov kev mob tshwm sim, nws lub peev xwm rau ntau- cov phiaj xwm kev tswj hwm ua rau nws tus qauv kev tshawb fawb hauv cov qauv tsiaj rau kev kawm txog kev coj tus cwj pwm nyuaj, ntsuas cov tswv yim tshiab neuromodulation, thiab tshawb nrhiav cov teebmeem ntawm neuropeptides ntawm kev xav thiab kev txawj ntse. Nws daim ntawv thov nyob rau hauv cov qauv kev ntxhov siab, kev ntsuam xyuas tus cwj pwm kev ntxhov siab, thiab kev ntsuam xyuas kev kawm thiab kev nco muab ib txoj hauv kev ua tau los tshawb txog lub cev kev ua haujlwm ntawm neuropeptides.
Daim ntawv thov Selank:
Raws li kev tshawb nrhiav neuropeptide, nws yog siv rau hauv cov qauv kev sim tshwj xeeb los ntsuas nws qhov muaj peev xwm cuam tshuam rau kev ua haujlwm ntawm neurotransmitter system thiab cov txiaj ntsig ntawm kev coj cwj pwm. Nws feem ntau yog siv los kawm txog cov txheej txheem ntawm kev coj tus cwj pwm thiab kev xav txog kev ntxhov siab, kev kawm, kev nco, thiab kev ntxhov siab.
Nws tau raug siv rau hauv kev tshawb fawb txog kev ntxhov siab thiab kev nyuaj siab -zoo li tsiaj cov qauv, kev ntsuas kev kawm thiab kev nco, cov qauv kev ntxhov siab ntev, thiab kev tswj hwm kev tiv thaiv kab mob. Nws zoo -txhais cov qauv tshuaj thiab cov txheeb ze ruaj khov muab cov cuab yeej tshawb fawb tus qauv rau kev ntsuam xyuas nws cov txiaj ntsig zoo ntawm lub hauv nruab nrab lub paj hlwb kev ua haujlwm thiab tus cwj pwm nyob rau hauv kev tswj xyuas kev sim.
Kev siv thiab kev khaws cia
1. Kev kho dua tshiab thiab kev npaj:
Cov kuab tshuaj pom zoo:
Nyiam cov kuab tshuaj: sterile dej rau kev txhaj tshuajlos yogsterile buffer (xws li PBS) nrog pH 5.5-7.0.
Rau kev txhaj tshuaj sab hauv: dilute nrog sterile saline.
Rau kev tswj hwm intranasal hauv kev tshawb fawb: nws tuaj yeem npaj nrog tsis muaj tshuaj lom isotonic saline.
Lus ceeb toom: Tsis txhob siv cov kua qaub uas muaj zog, cov hauv paus muaj zog, lossis cov kev daws teeb meem uas muaj cov kuab tshuaj organic.
Tus txheej txheem npaj:
Solvent npaj:
Siv cov kuab tshuaj uas tau lim sterilely los ntawm 0.22 μm lim membrane.
Qhov ntsuas kub hnyav tau rov qab los rau hauv chav sov (20-25 degree).
Reconstitution txheej txheem:
Ntxiv 1.0 mL ntawm cov kuab tshuaj pom zoo rau 5 mg vial.
Ncuav maj mam raws lub raj mis phab ntsa kom tsis txhob cuam tshuam ncaj qha rau cov hmoov.
Maj mam tig lub vial rau 3-5 feeb kom txog thaum yaj tag, tsis txhob muaj kev sib tsoo uas yuav ua rau muaj npuas.
Qhov kawg concentration: 5 mg / mL (kwv yees li 6.65 mM).
Dispensing thiab dilution:
Tam sim ntawd muab tso rau hauv ib zaug - siv koob tshuaj 10-50 μL siv cov tshuaj qis qis qis.
Dilute mus rau qhov yuav tsum tau ua hauj lwm concentration nrog sterile saline, PBS, los yog ib tug haum cov cab kuj.
Daim ntawv qhia meej: lub npe, concentration, hnub npaj, batch naj npawb.
Ua hauj lwm concentration/dosage reference:
Kev sim hauv vitro cell: Qhov feem ntau siv concentration ntau yog 0.1 μM txog 10 μM, thiab cov kev sim ua ntej yuav tsum tau ua kom zoo dua qhov concentration raws li hom cell tshwj xeeb thiab lub hom phiaj kev sim.
Tsiaj hauv vivo sim:
Intraperitoneal / subcutaneous txhaj tshuaj: Qhov ntau npaum li cas yog 50 txog 300 ug / kg.
Intranasal kev tswj hwm: Cov concentration thiab ntau npaum li cas yuav tsum tau txiav txim siab raws li cov qauv kev tshawb fawb tshwj xeeb, thiab feem ntau yog cov tshuaj tsawg.
Nws raug pom zootias cov koob tshuaj raug txiav txim siab raws li qhov kev sim ua ntej, txoj hauv kev tshwj xeeb ntawm kev tswj hwm, thiab kev coj noj coj ua ntawm tsiaj.
Piv txwv ntawm kev npaj xam: Yog tias xav tau 100 μM kev ua haujlwm, siv li 15 μL ntawm cov tshuaj hauv Tshuag thiab ntxiv rau 1 mL ntawm kab lis kev cai nruab nrab lossis hnyav.
Cov ntsiab lus tseem ceeb kom nco ntsoov:
Dissolve maj mam: Tsis txhob swirling lossis ua nruj ua tsiv; yooj yim tig maj mam kom yaj.
Cov txheej txheem nruj aseptic: Ua haujlwm hauv lub rooj zaum huv si thiab siv cov khoom siv tsis muaj menyuam, tshwj xeeb tshaj yog thaum muab tshuaj rau sab hauv lossis intranasally.
Kom tsis txhob muaj teeb pom kev zoo: Nws yog rhiab rau lub teeb, thiab tag nrho cov kauj ruam yuav tsum tau ua nyob rau hauv lub teeb - tiv thaiv tej yam kev mob.
Npaj thiab siv tam sim ntawd: Qhov kev ruaj ntseg yog txwv tom qab kev kho dua tshiab, yog li nws raug pom zoo kom siv nws sai li sai tau. Tom qab rov ntim dua, khaws cia rau hauv cov xwm txheej tshwj xeeb.
Kom tsis txhob adsorption: dilution nrog cov tshuaj uas muaj 0.1% bovine serum albumin los yog silanized qis-cov hlab adsorption tuaj yeem txo cov adsorption ntawm phab ntsa ntawm lub raj.
2. Cia tej yam kev mob:
Unreconstituted lyophilized hmoov:
Ntev - lub sij hawm cia: khov ntawm -20 degree, txee lub neej 24 lub hlis.
Kev cia zoo: -80℃tob khov, txee lub neej 36 lub hlis.
Kev tiv thaiv nruj ntawm lub teeb: Yuav tsum muab khaws cia rau hauv lub teeb qub- pov thawj aluminium foil hnab.
Kev tiv thaiv noo noo: Khaws qhuav; muaj desiccant.
Reconstituted daws:
Siv tam sim ntawd: Rau kev ua haujlwm zoo tshaj plaws, siv tam sim tom qab hloov kho.
Short - lub sij hawm cia: Txias ntawm 2-8℃deb ntawm lub teeb, tsis pub ntau tshaj 24 teev.
Repackage thiab khov: Khaws ntawm -20℃lossis -80℃deb ntawm lub teeb tsis pub ntau tshaj 1 lub lis piam.
Rov qab khov-thaw cycles raug txwv nruj heev: qhov siab tshaj plaws ntawm ib qho khov -thaw voj voog.
Kev thauj mus los:
Txias- cov hmoov qhuav: thauj los ntawm cov dej khov qhuav (-78 degree).
Luv - lub sij hawm shipping: 2-8℃ice pob shipping, xyuas kom tus me nyuam tsis pub dhau 48 teev.
Ntim: Lub teeb- pov thawj aluminium foil hnab + lub tshuab nqus tsev foob + ua npuas ncauj insulated lub thawv.
3. Kev ruaj ntseg thiab cov qauv ua tiav:
Tshuaj thiab lub cev stability:
Nws yog qhov ruaj khov nyob rau hauv aqueous daws nrog pH ntawm 5.0-7.0.
Tsis txhob sib cuag nrog cov kua qaub uas muaj zog, muaj zog alkalis, thiab oxidizing tus neeg sawv cev.
Nws yog rhiab heev rau kub thiab mechanical kev nyuaj siab.
Kev kho ntawm bioactivity:
Kev xa tawm kom raug thiab khaws cia ntawm -80℃yog qhov tseem ceeb rau kev tswj hwm kev ua haujlwm mus ntev.
Thaw thiab muab cov kua dej maj mam tso rau hauv dej khov los yog hauv tub yees ua ntej siv.
Xav taudab tsi, thov hu raupeb
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Cim npe nrov: Selank 5mg / vial zoo txo kev ntxhov siab, stabilizes mus ob peb vas, thiab txhim khu kev txawj ntse, Tuam Tshoj selank 5mg / vial zoo relieves ntxhov siab vim, stabilizes mus ob peb vas, thiab txhim khu kev txawj ntse muaj nuj nqi manufacturers, lwm tus neeg, Hoobkas
