Sr 9009 10 mg * 100 / lub raj mis Stromusc slarset ntawm cov ntsiav tshuaj ntawm qhov ncauj

SR9009 (Rev {{- Nrhiav 100 ntsiav tshuaj 100 ntsiav tshuaj tseem ceeb*

Kws muag tshuaj -} qib raw cov ntaub ntawv|SR9009 (Circadian Cov Lus Regulator)

Tshuaj lom neeg npe: (R) -2 - ((3,5-Dadethyl-4- (4- (Methyldhof-4- ((4-) Pyridin-2-YL) Methylamino) -2-Phenylethanol

Tus lej: 1379686-29-8

Einecs tooj: Kom raug muab

Molecular cov mis: c₂₃h₂₆n₂o₂s

Molecular hnyav: 394.53

Melting taw tes: 142-145 degree

Zog: Dawb Crystalline Hmoov

Purity: ntau dua los yog sib npaug rau 98% (HPLC sim)

Cov khoom tseem ceeb

SR9009 yog aRev - erb nuclear receptor agonistCov. Vim nwsCov cim kev cai tshwj xeeb raws cov kev cai lij choj thiab cov kev tswj hwm metabolic, nws yog dav sivHauv Kev Tshawb Xyuas Kab Mob Me Meatolic, Kev Ua Si Ncaws Pob Ua Haujlwm, thiab Kev cai metabolism hauv lub zog.

✅ Kev tswj cov circadian kev tswj kev mechanism:

Rev - erb ua kom muaj kev ua kom: Tshwj xeeb lub Rev - erb nuclear receptor thiab tswj hwm hluav taws xob cov gene

Cov Kev Tswj Xyuas Kev Sib Koom Metabolic: Cuam tshuam cov caj ces cuam tshuam rau cov metabolism, lipid metabolism, thiab cov zog sib npaug

Mitochondrial biogenesis: Txhawb Mitochondrial tiam thiab ua haujlwm

✅ Kev Ua Si Kev Ua Si Txhim Kho:

10 kev kwv yees: Cov kev tshawb fawb preclinical tau qhia tau ib qho kev nce qib tseem ceeb hauv kev ua kom ntev dua 50%.

Zog metabolism kho kom zoo: txhim kho kev siv hluav taws xob kev ua tau zoo thiab ua kom muaj kev tawm dag zog nce

Koom haum nrawm nrawm: Txo oxidative kev ntxhov siab thiab mob tom qab qoj ib ce

✅ Metabolism -} txhim kho cov khoom:

Cov Kev Cai Las Loos: Txhim kho cov kua qaub ua tsaug rau thiab cov tshuaj insulin

Lipid metabolism txoj cai: Txo cov ntshav hluav taws xob triglyceride thiab qis -} cov lipoprotein ntau ntau

Kev tswj qhov hnyav: Txo cov roj zuj zus thiab txhim kho lub cev muaj pes tsawg leeg

Kawg Cov Khoom Qhia Khoom Siv Khoom Taw Qhia

1. Npaj ntawm zaj duab xis - coated ntsiav tshuaj (10 mg / ntsiav tshuaj):

Piv Txwv Piv Txwv(rau 1000 ntsiav tshuaj):

SR9009 RAW KHOOM: 10.0g

Microcrystalline Cellulose: 80.0g

Lactose: 50.0g

Hla -} Txuas cov carboxymethyl cellulose sidium: 8.0g

Magnesium Stearate: 2.0g

Npaj txheej txheem:

Cov Khoom Siv Raw Ua Ntej: Micronization (D90 tsawg dua los yog sib npaug rau 10μm)

Cov nqi sib xyaw sib xyaw: maj mam sib tov nrog rau dituent

Ntub av granulle: Granulate nrog cov nyiaj uas tsim nyog ntawm cov dej lim thiab qhuav hauv txaj hauv 50 degree

Granulation: 20 Mesh Sab Canules, ntxiv Flow AIDS thiab roj nplua nyeem

Ntsiav tshuaj: 8mm round tuag, 8-10kn siab ntsiav tshuaj

Zaj duab xis txheej: Enteric txheej los txhim kho Bioavailability

Kev Tswj Xyuas Zoo:

Cov ntsiab lus sib xyaw: RSD tsawg dua lossis sib npaug rau 3% (HPLC Nrhiav tau)

Kev Tawm Tsam: Loj dua lossis sib npaug rau 80% enteric tso tawm hauv 45 feeb (duav txheej txheem, 50 rpm)

Lwm yam tshuaj: Ib leeg impurity tsawg dua los yog sib npaug rau 0.5%, tag nrho cov impurities tsawg dua los yog sib npaug rau 1.0%

Cov kev siv raws tu qauv

1. Kev Tshawb Fawb Txog Kev Tshawb Fawb:

Pib koob tshuaj:

10 mg / hnub, coj ob zaug ib hnub (5 mg thaum sawv ntxov thiab 5 mg nyob rau yav tsaus ntuj)

Kev Ntsuam Xyuas Kev Ntsuas Rau 1 Lub Limtiam

Txij Nkawm Koob:

20-30 mg / hnub, muab faib ua 2-3 koob

Cov koob tshuaj tshaj plaws: tsis muaj ntau tshaj 50 mg / hnub

2. Thaum siv:

Noj thaum sawv ntxov:

Siv thawj koob tshuaj 30 feeb ua ntej noj tshais

Kev tswj hwm nruab hnub metabolic kev ua ub no

Ua ntej qoj ib ce:

Siv 60 feeb ua ntej kev tawm dag zog

Txhim kho kev ua kom ntev ntev thiab cov rog siv

3. Kev tswj hwm kev tswj hwm:

Luv - lus kawm: 4-8 lub lis piam

Ntev - sij hawm kawm: 8-12 lub lis piam (Kaw kev saib xyuas circadian rhyosh

Tshaj tawm - kev mus kuaj xyuas: Txuas ntxiv saib xyuas kev rov qab ntawm biological rhythms rau 2-4 lub lis piam tom qab cheem cov tshuaj

Vim li cas thiaj xaiv SR9009 cov khoom siv raw?

Kev Tsim Hluav Taws Xob: Thawj metabolic modulator tsom lub rev - ereb receptor

Ntau yam kev pab cuam: Ib txhij txhim kho metabolic noj qab haus huv, kev ua kis las, thiab cov metabolism hauv lub zog

Kev tshawb nrhiav tus nqi: Nws muaj cov tseem ceeb tshawb fawb nyob rau hauv cov liaj teb ntawm cov kab mob metabolic thiab cov kis las

Tag

SR9009 yogIb qho cuab yeej tseem ceeb hauv kev kawm ntawm cov kev cai metabolic.DhauKev Tshawb Fawb Tsim Txheej Txheem,Nws tuaj yeem tsim rau hauvNtau yam cov ntawv ntau npaum li cas, suav nrog qhov ncauj nkag - coated ntsiav tshuajCov. Xaiv peb kom ntseeg tausiab -} Purity raw cov ntaub ntawv, kev txhawb nqa kev ua haujlwm, thiab muaj txhij txhua {{1} kev pab muag khoom.

Xav taudab tsi, thov hu raupeb

Cim npe nrov: sr 9009 10 mg * 100 / lub raj mis Stromusc slaivrets ntawm Qhov Rooj Ntaub Ntawv ntawm Qhov Muag Qhia Txog Qhov Muag Qhia Txog Qhov Muag Qhia Txog Qhov Muag Qhia Txog Qhov Muag Qhia Txog Qhov Muag Qhia Txog Qhov Muag Qhia Txog Qhov Muag Qhia Qhov Rooj Ntawm Qhov Chaw Ntawm Qhov Rooj Qhia Qhov Muag Qhia, Chaw muag khoom, Hoobkas