Semax 5mg / vial tseem ceeb txhim kho kev paub txog kev ua haujlwm, txhim kho kev puas siab puas ntsws, thiab txhawb nqa neuroprotection.

Semax 5mg / lub raj mis kev taw qhia

Neuroprotective peptides|Lub paj hlwb- muab tau los ntawm neurotrophic yam mimic peptides 5mg / vial

Lub npe: Smith

Ib ntus: Ntsib-Glu-Nws-Phe-Pro-Gly-Pro

Molecular hnyav:kwv 813.9 da

Purity: Ntau dua lossis sib npaug li 99.0% (HPLC)

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: khov ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab cia

Smecta yog ib qho hluavtaws peptide muab tau los ntawm ib feem ntawm adrenocorticotropic hormone (ACTH) thiab muaj zog neuroprotective, neurotrophic, thiab kev txawj ntse - txhim kho cov khoom. Tsis zoo li cov tshuaj neuropharmaceuticals ib txwm muaj, Smecta txhim kho neuroplasticity thiab txhim kho lub hlwb cov tshuaj tiv thaiv antioxidant los ntawm kev tswj cov kev qhia ntawm lub hlwb - tau txais txiaj ntsig neurotrophic (BDNF). Nws cov teebmeem pleiotropic tshwj xeeb ua rau nws muaj txiaj ntsig rau kev kawm cov kab mob neurodegenerative, ischemic hlwb raug mob, kev paub tsis meej, thiab cov txheej txheem ntawm kev kawm thiab kev nco. Nws muaj peev xwm ua tau zoo hla cov ntshav- lub paj hlwb teeb meem kuj tau txais kev saib xyuas tseem ceeb hauv kev tshawb fawb hauv nruab nrab paj hlwb.

Vim nws qhov kev txhim kho tseem ceeb ntawm kev paub txog kev ua haujlwm thiab cov khoom tiv thaiv neuroprotective, ntau tus kws tshawb fawb neuroscience thiab cov kws tshawb fawb hauv kev paub txog kev txawj ntse nyiam siv Smecta. Nws tsis ua los ntawm cov tshuaj hormones receptors, tab sis los ntawm kev cuam tshuam cov paj hlwb kev loj hlob thiab cov neurotransmitter metabolism, yog li tsis txhob muaj cov kev mob tshwm sim nyuaj. Nws lub peev xwm los txhim kho kev kawm, kev nco, thiab kev saib xyuas, nrog rau nws muaj peev xwm tiv thaiv - kev ntxhov siab thiab tiv thaiv - ntxhov siab vim, ua rau nws muaj txiaj ntsig zoo hauv kev tshawb fawb txog kev paub txog kev txawj ntse, kev kho mob hlwb, thiab cov qauv ntawm kev puas siab puas ntsws.

Smex txhim kho neuroplasticity, txhawb nqa BDNF qhia, txhim kho kev kawm thiab kev nco, thiab muab cov teebmeem neuroprotective. Nws yog ib qho hluavtaws neuropeptide raws li ACTH fragment, nthuav tawm cov teebmeem tseem ceeb hauv kev tswj hwm lub hauv paus paj hlwb kev ua haujlwm thiab txhim kho kev txawj ntse.

Smecta yog siv dav hauv neuroscience, kev paub txog kev puas siab puas ntsws, thiab kev tshawb fawb neuropharmacology. Nws muaj peev xwm tswj hwm ntau lub tshuab neurotransmitter, nrog rau nws cov kev txhawb nqa ntawm neuronal survival thiab synaptic plasticity, ua rau nws muaj txiaj ntsig thiab muaj txiaj ntsig tshwj xeeb rau kev kawm Alzheimer's disease, Parkinson's disease, post-stroke recovery, traumatic brain raug mob, thiab cov tswv yim txhim kho kev txawj ntse.

Txoj kev siv thiab khaws cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Nyiam cov kuab tshuaj: sterile dej rau kev txhaj tshuajlos yogsterile physiological saline (0.9% NaCl)

Rau cov kev tshawb fawb intranasal: sterile isotonic salinelos yogib tug tshwj xeeb sterile qhov ntswg hnyav(pH 5.5-7.0).

Rau kev sim tsiaj: dissolve nyob rau hauv sterile physiological saline.

Tus txheej txheem npaj:

Solvent npaj:

Cov kuab tshuaj tau sterile lim los ntawm 0.22 μm lim membrane.

Rov qab cov kuab tshuaj mus rau chav sov (20-25 degree).

Reconstitution txheej txheem:

Ntxiv 1.0 mL ntawm cov kuab tshuaj pom zoo rau 5 mg vial.

Ncuav maj mam raws lub raj mis phab ntsa, tsis txhob muaj kev cuam tshuam hnyav.

Maj mam tig lub vial rau 2-3 feeb kom txog thaum yaj tag.

Qhov kawg concentration: 5 mg / mL (kwv yees 6.1 mM)

Cais thiab khaws cia:

Tam sim ntawd muab tso rau hauv ib zaug - siv cov koob tshuaj uas siv qis - cov raj centrifuge adsorption.

Clear labeling: Khoom npe, concentration, npaj hnub, batch tooj

Khaws deb ntawm qhov kaj

Ua hauj lwm concentration/dosage reference:

Kev sim hauv vitro cell: Feem ntau siv cov concentration ntau yog 0.1 μM txog 10 μM

Tsiaj hauv vivo sim: Kev siv ntau npaum li cas yog 50 ug / kg txog 300 ug / kg

Piv txwv ntawm kev npaj xam: Yog tias yuav tsum muaj 100 μM kev daws teeb meem, siv 16.4 μL ntawm cov tshuaj hauv Tshuag thiab ntxiv rau 1 mL ntawm kab lis kev cai nruab nrab.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Cov txheej txheem aseptic: Kev npaj ua tiav hauv lub txee biosafety.

Lub teeb zam kev xav tau: Sensitive rau lub teeb, kev khiav hauj lwm yuav tsum tau ua nyob rau hauv qhov tsaus ntuj nti.

Solubility: Soluble zoo nyob rau hauv dej thiab physiological saline.

Tsis txhob adsorption: Siv cov khoom siv uas tsis tshua muaj adsorption.

Npaj thiab siv tam sim ntawd: Nws raug nquahu kom siv tam sim tom qab hloov kho.

Qhov ntswg formulation: Thaum siv nyob rau hauv kev tshawb fawb tshuaj intranasal, yuav tsum tau siv cov kuab tshuaj uas tsis muaj menyuam.

2. Cia tej yam kev mob:

Unreconstituted lyophilized hmoov:

Ntev - lub sij hawm cia: Frozen ntawm -20 degree, txee lub neej 24 lub hlis

Kev cia zoo: -80℃(ntub khov), txee lub neej 36 lub hlis.

Kev tiv thaiv lub teeb: Khaws rau hauv lub hnab ntawv aluminium qub kom deb ntawm lub teeb.

Cov dej noo- pov thawj cia: Ua-hauv desiccant, txheeb ze av tsawg dua los yog sib npaug li 60%.

Reconstituted daws:

tam sim ntawdtom qab kev kho dua tshiab rau kev ua haujlwm zoo.

Short - lub sij hawm cia: Txias ntawm 2-8℃tsis pub ntau tshaj 12 teev.

Repacking thiab khov: Rov ntim thiab khov ntawm -20℃tsis pub ntau tshaj 7 hnub.

Txias-thaw lub voj voog txwv nruj heev: qhov siab tshaj plaws ntawm ib qho khov -thaw lub voj voog raug tso cai.

Kev thauj mus los:

Kev thauj mus los txiasCov dej khov qhuav qhuav (hauv qab -78 degree)

luv - tsheb thauj mus losKev thauj mus los: 2-8℃ice pob, tsis pub dhau 24 teev.

Ntim txheem: Lub teeb- pov thawj aluminium foil hnab + lub tshuab nqus tsev ntim + insulated lub thawv

Tsheb thauj mus los labeling: Qhia meej meej "cov khoom siv roj ntsha", "tsis kub", thiab "tiv thaiv lub teeb."

3. Tswj kev ruaj ntseg:

Kub stability:

-80℃: >3 xyoo

-20℃: >2 xyoo

2-8 degree: Tsawg dua lossis sib npaug li 12 teev (kev daws teeb meem)

Chav ntsuas kub: Tsawg dua lossis sib npaug li 4 teev (kev daws teeb meem)

Tshuaj stability:

Qhov zoo tshaj pH ntau: 5.0-7.5

Tsis txhob muaj zog acid thiab muaj zog alkaline ib puag ncig.

Lub teeb ruaj khov:

Sensitive rau ultraviolet lub teeb

Tag nrho cov txheej txheem yuav tsum tau ua nyob rau hauv qhov tsaus ntuj nti.

Microbial stability:

Cov txheej txheem nruj aseptic

Siv cov kuab tshuaj sterile thiab consumables

Xav taudab tsi, thov hu raupeb

Cim npe nrov: semax 5mg / vial ho txhim kho kev txawj ntse, txhim kho kev puas siab puas ntsws, thiab txhawb kev tiv thaiv kab mob. manufacturers, lwm tus neeg, Hoobkas