Semaglutide 5mg / vial Zoo tswj qhov hnyav, txhim kho cov ntshav qab zib thiab kev noj qab haus huv metabolic

Semaglutide 5mg / lub raj mis qhia

Ntev- ua haujlwm GLP-1 receptor agonist|Muaj peev xwm txo qis qabzib thiab tswj qhov hnyav peptide 5mg / vial

Lub npeTom ntej: Smegglutinin

Ib ntus: Raws li cov qauv ntawm tib neeg GLP-1 (7-37), hloov nrog peptide thiab fatty acid sab chains.

Molecular hnyav: kwv yees 4113.6 Da

Purity: Ntau dua lossis sib npaug li 99.0% (HPLC)

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: khov ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab cia

Semaglutide:

Smegglutide yog ib qho engineered, ntev - ua glucagon-zoo li peptide-1 (GLP-1) analogue. Los ntawm optimized amino acid sequence thiab fatty acid side chain modifications, nws ib nrab -lub neej yog ho ntev, ua kom muaj txiaj ntsig zoo ib zaug ib lim piam rau cov ntshav qabzib thiab tswj qhov hnyav. Tsis zoo li tej yam ntuj tso GLP-1 los yog lwm yam luv luv-acting analogues, nws muaj zog thiab txhawb nqa GLP-1 receptor agonist kev txiav txim tsis tsuas yog txhawb cov insulin secretion, inhibits glucagon, thiab qeeb plab hnyuv, tab sis kuj zoo suppresses qab los ntawm lub hauv paus paj hlwb kev ua. Nws cov txiaj ntsig zoo tshaj plaws thiab kev siv tshuaj yooj yim ua rau nws yog ib qho cuab yeej nyiam hauv kev tshawb fawb txog cov txheej txheem pathological thiab cov tswv yim kho mob rau hom 2 mob ntshav qab zib, rog rog, thiab cuam tshuam txog cov teeb meem metabolic.

Vim nws tau lees paub qhov hnyav poob thiab cov piam thaj hauv ntshav- txo cov teebmeem, nrog rau kev yooj yim ntawm kev siv tshuaj txhua lub limtiam rau kev tshawb fawb, smegglutinin yog qhov kev xaiv zoo tshaj plaws rau ntau tus kws tshawb fawb hauv cov kab mob metabolic. Nws tsis ua los ntawm txoj hauv kev ib txwm muaj anabolic lossis androgenic, tab sis qhov tseeb yog lub hom phiaj ntawm GLP-1 receptor, zam kev sib deev tsis sib haum xeeb- cuam tshuam txog kev phiv. Nws lub luag haujlwm tseem ceeb hauv kev tswj hwm lub zog sib npaug, kev coj cwj pwm noj mov, thiab cov piam thaj hauv tsev ua rau nws ua tau zoo, txhim khu kev qha, thiab zoo-txhais lus tshawb fawb cov cuab yeej rau kev kawm metabolic syndrome, tsis yog- kab mob cawv fatty siab (NAFLD), thiab cov teeb meem kev rog rog.

Kev siv Semaglutide:

Nws muaj zog ua kom lub GLP-1 receptors, txhawb cov insulin secretion thiab inhibiting glucagon nyob rau hauv ib tug qabzib -raws li txoj cai, zoo ncua lub plab khoob thiab ua rau lub hauv paus ntawm satiety. Smegglutinin yog ib lub sijhawm ntev - ua haujlwm hypoglycemic thiab poob peptide tsim los ntawm kev hloov kho peptide siab heev, thiab yog ib qho qauv ntsuas hauv kev tshawb fawb metabolic.

Smegglutide yog siv dav hauv kev tshawb fawb ua ntej thiab kev txhais lus ntawm hom 2 mob ntshav qab zib, rog rog, thiab cov kab mob metabolic. Nws lub hom phiaj zoo- tau txhais lub hom phiaj thiab cov yam ntxwv zoo ntawm cov tshuaj pharmacodynamic muab lub siab - cov qauv kev tshawb fawb zoo rau kev tshawb nrhiav cov txheej txheem ntawm cov tshuaj hypoglycemic tshiab thiab qhov hnyav- cov tshuaj poob, ntsuas kev sib xyaw ua ke kev kho mob, thiab kawm ntev - cov tswv yim tswj xyuas cov kab mob metabolic. Nws tseem yog ib qho tseem ceeb hauv kev tshawb fawb tshawb nrhiav lub zog metabolism, pub cov kab mob neural, thiab cov kab mob siab lipid metabolism.

Txoj kev siv thiab khaws cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Nyiam cov kuab tshuaj: Cov tshuaj muaj sterile diluentlos yogib qho kev daws teeb meem tsis haum nrog pH 8.0-8.5.

Lus Cim Tseem Ceeb: Tsis txhob siv cov ntsev zoo tib yam, cov dej tsis muaj menyuam rau kev txhaj tshuaj, lossis lwm yam kuab tshuaj uas tsis tau lees paub, vim qhov no yuav ua rau cov tshuaj nag lossis daus, inactivation, lossis teeb meem kev ruaj ntseg.

Rau kev sim dilution: Tom qab dissolving nyob rau hauv cov saum toj no -hais tshwj xeeb hnyav hnyav, nws yuav tsum diluted zaum ob nrogphysiological saline muaj 0.1% bovine serum albumin (BSA).

Tus txheej txheem npaj:

Solvent npaj:

Siv cov kuab tshuaj uas tau ua kom tsis muaj menyuam los ntawm 0.22μm lim membrane.

Qhov ntsuas kub hnyav tau rov qab los rau hauv chav sov (20-25 degree).

Reconstitution txheej txheem:

Ntxiv 1.0 mL ntawm cov kuab tshuaj tshwj xeeb rau 5 mg vial.

Ncuav maj mam raws lub raj mis phab ntsa kom tsis txhob muaj kev cuam tshuam ncaj qha rau lub khov - ncuav mog qab zib qhuav.

Maj mam tiglub vial horizontally nyob rau hauv xib-teg ntawm koj txhais tes rau yam tsawg kawg yog 2-3 feeb kom txog rau thaum ib tug ntshiab los yog me ntsis opalescent cov ntaub ntawv.Kev tshee tshee, tshee, lossis vortexing yog txwv tsis pub.

Qhov kawg concentration: 5 mg / mL (kwv yees li 1.2 mM).

Dispensing thiab dilution:

Yog tias tsis siv tam sim ntawd, nws yuav tsum tau muab xa mus rau hauv ib qho - kev sim kom muaj nuj nqis uas siv qis - cov raj xa dej cryopreservation kom sai li sai tau.

Rau qis concentration, sivphysiological saline muaj 0.1% BSArau gradient dilution thiab maj mam invert mus sib tov.

Ua hauj lwm concentration/dosage reference:

Kev sim hauv vitro cell: Feem ntau siv cov concentration ntau yog 0.1 nM txog 100 nM

Tsiaj hauv vivo sim: Kev siv ntau npaum li cas yog 0.01 txog 0.3 mg / kg (subcutaneous txhaj).

Piv txwv ntawm kev npaj xam: Yog tias xav tau 10 nM kev daws teeb meem, noj 8.3 μL ntawm cov tshuaj hauv Tshuag thiab ntxiv rau 1 mL ntawm kab lis kev cai nruab nrab.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Solvent specification: Cov kuab tshuaj tshwj xeeb yuav tsum tau siv, uas yog ib qho tseem ceeb los xyuas kom meej nws solubility thiab ntev - cov khoom kav ntev.

Cov txheej txheem dissolving: Dissolve tsuas yog maj mam tig kab rov tav. Ib qho kev tuav nruj heev tuaj yeem ua rau cov protein denaturation lossis sib sau ua ke.

Aseptic thiab lub teeb -cov txheej txheem tiv thaiv: Kev ua haujlwm nruj aseptic thiab ua tiav kev tiv thaiv los ntawm lub teeb thoob plaws hauv cov txheej txheem.

Saib xyuas qhov kev daws teeb meem: Cov tshuaj yuav tsum tau meej los yog me ntsis opalescent tom qab reconstitution. Yog hais tias nag lossis daus, fibers lossis discoloration tshwm sim, cov tshuaj yuav tsum muab pov tseg.

Npaj -rau- siv: Tom qab kev kho dua tshiab, nws yuav tsum tau sivhauv 1 teev, los yog khaws cia luv luv raws li tau teev tseg.

2. Cia tej yam kev mob:

Unreconstituted lyophilized hmoov:

Ntev - lub sij hawm cia: Khaws khov ntawm -20 degree, txee lub neej 24 lub hlis.

Kev cia zoo: Khaws khov ntawm -80 degree, txee lub neej 36 lub hlis.

Kev tiv thaiv nruj ntawm lub teeb: Yuav tsum muab khaws cia rau hauv lub teeb qub- pov thawj aluminium foil hnab.

Kev tiv thaiv noo noo: Khaws qhuav; muaj desiccant.

Reconstituted daws:

Siv tam sim ntawd: Rau kev ua haujlwm zoo tshaj plaws, siv tam sim tom qab hloov kho.

Short - lub sij hawm cia: Khaws ntawm 2-8℃deb ntawm lub teeb tsis pub ntau tshaj 24 teev.

Kev khov yog txwv nruj heev: Cov kev daws teeb meem uas tau muab kho dua yuav tsum tsis txhob khov dua.

Kev thauj mus los:

Txias- cov hmoov qhuav: thauj los ntawm cov dej khov qhuav (-78 degree).

Ntim: Lub teeb- pov thawj aluminium foil hnab + lub tshuab nqus tsev foob + ua npuas ncauj insulated lub thawv.

3. Kev ruaj ntseg thiab cov qauv ua tiav:

Physicochemical stability:

Nws yog qhov ruaj khov tshaj plaws nyob rau hauv pH tej yam kev mob ntawm ib qho hnyav hnyav.

Nws yog rhiab heev rau cov kev hloov pauv hauv pH thiab ionic zog ntawm cov uas tsis yog- cov kuab tshuaj tshwj xeeb thiab muaj kev sib sau ua ke.

rhiab heev rau txhua yam kev ntxhov siab (xws li kev vibration hnyav).

Cov ntsiab lus tseem ceeb rau khaws cia cov khoom xyaw nquag:

Kev ua raws cai nruj rau cov txheej txheem kev sib cais thiab cov txheej txheem dilution yog qhov tseem ceeb rau kev tswj hwm nws cov kev ua haujlwm lom neeg thiab ntev ntev - cov tshuaj pharmacokinetic kav ntev.

Xav taudab tsi, thov hu raupeb

Cim npe nrov: Semaglutide 5mg / vial zoo tswj qhov hnyav, txhim kho ntshav qab zib thiab kev noj qab haus huv metabolic, Tuam Tshoj semaglutide 5mg / vial zoo tswj, txhim kho ntshav qab zib thiab metabolic noj qab haus huv manufacturers, lwm tus neeg, Hoobkas