Gonadorelin 2mg / vial Restore Fertility

Gonadorelin 2mg / lub raj mis qhia

Ntuj Gonadotropin-Tshuaj Hormone|Decapeptide GnRH Agonist 2 mg / lub raj mis

Lub npe: Gonarelin ib

English npeLossis: Gonadorelin

Ib ntus: pGlu-Nws-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂

Molecular hnyav: Kwv yees li 1182.3 Da

Purity: Ntau dua lossis sib npaug li 98.0% (HPLC)

Cov ntsiab lus: 2mg / lub raj mis

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: khov ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab cia

Gonadorelin:

Gonareline yog ib qho hluavtaws decapeptide ntawm ntuj gonadotropin - tso cov tshuaj hormones (GnRH), zoo ib yam li endogenous GnRH secreted los ntawm hypothalamus. Nws ua raws li lub cev pulsatile GnRH secretion, ua rau GnRH receptors nyob rau hauv lub anterior pituitary caj pas los txhawb lub synthesis thiab tso tawm ntawm luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH). Nws luv- ua yeeb yam, pulsatile xwm ua rau nws muaj txiaj ntsig rau kev kawm hypothalamic-pituitary-gonadal axis muaj nuj nqi, ntsuas pituitary teb rau GnRH, thiab tshawb nrhiav cov txheej txheem ntawm kev tsim cov kab mob endocrine.

Vim nws cov qauv zoo ib yam thiab cov txheej txheem ntawm kev txiav txim rau endogenous GnRH, gonadorelin tau siv dav hauv kev ua me nyuam endocrinology, kev tshawb fawb tsis muaj menyuam, thiab kev ntsuas kev ua haujlwm gonadal. Piv nrog rau ntev - ua yeeb yam GnRH analogs, nws luv luv - ua yeeb yam tso cai rau nws ua kom raug ntau dua li kev ua lub cev pulsatile secretion, muab cov cuab yeej zoo tshaj plaws rau kev kawm pituitary -gonadal axis muaj nuj nqi, ntsuas gonadotropin reserves, thiab tshawb txog kev sib deev hormone tawm tswv yim mechanisms.

Daim ntawv thov Gonadorelin:

Nws khi rau GnRH receptors nyob rau hauv lub anterior pituitary caj pas, stimulating lub synthesis thiab tso tawm ntawm luteinizing hormone thiab follicle-stimulating hormone, yog li txhawb lub secretion ntawm kev sib deev hormones. Gonarelin yog ib qho cuab yeej tseem ceeb rau kev kawm txog kev ua haujlwm ntawm hypothalamus-pituitary-gonadal axis, ntsuas pituitary gonadotropin reserves, thiab tshawb xyuas cov txheej txheem ntawm kev tsim cov kab mob endocrine.

Gonarelin yog dav siv nyob rau hauv kev ua me nyuam endocrinology, infertility mechanism kev tshawb fawb, thiab gonadal kev ntsuam xyuas. Nws zoo-txhais cov tshuaj pharmacological ntawm kev nqis tes ua muab lub siab zoo- qauv kev tshawb fawb zoo rau kev soj ntsuam pituitary teb rau GnRH, kawm txog kev tswj hwm kev sib deev cov tshuaj hormones, thiab tshawb nrhiav cov kab mob ntawm cov kab mob hauv lub cev.

Txoj kev siv thiab khaws cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Nyiam cov kuab tshuaj: sterile dej rau kev txhaj tshuajlos yogsterile sodium acetate tsis tov nrog pH 5.0-7.0.

Kev ruaj ntseg optimization: Sterile dej rau txhaj tshuaj muaj 0.1% mannitol

Rau kev txhaj tshuaj sab hauv: dilute nrog sterile saline.

Lus ceeb toom: Tsis txhob siv cov kuab tshuaj alkaline lossis cov kuab tshuaj uas muaj cov tshuaj tua kab mob (xws li benzyl cawv).

Tus txheej txheem npaj:

Solvent npaj:

Cov kuab tshuaj tau sterile lim los ntawm 0.22 μm lim membrane.

Qhov ntsuas kub hnyav tau rov qab los rau hauv chav sov (20-25 degree).

Reconstitution txheej txheem:

Ntxiv 1.0 mL ntawm cov kuab tshuaj pom zoo rau 2 mg vial.

Maj mam ncuav cov hmoov raws lub raj mis phab ntsa kom tsis txhob cuam tshuam ncaj qha rau cov hmoov.

Maj mam tig lub vial rau 3-5 feeb kom txog thaum yaj tag.

Qhov kawg concentration: 2 mg / mL (kwv yees 1.69 mM)

Dispensing thiab dilution:

Tam sim ntawd muab tso rau hauv ib zaug - siv koob tshuaj 20-50 μL siv cov tshuaj qis qis qis.

Dilute mus rau qhov yuav tsum tau ua hauj lwm concentration nrog sterile saline los yog PBS.

Clear labeling: Lub npe, concentration, npaj hnub, batch tooj

nruj me ntsis zam lub teeb thaum ua haujlwm.

Ua hauj lwm concentration/dosage reference:

Kev sim hauv vitro cell: Feem ntau siv cov concentration ntau yog 0.1 nM txog 1 μM

Tsiaj hauv vivo sim: Feem ntau siv ntau npaum li cas yog 50 mus rau 500 ug / kg (subcutaneous lossis intravenous txhaj, tswj pulsatilely raws li txoj cai kawm).

Piv txwv ntawm kev npaj xam: Yog tias xav tau 1 μM kev daws teeb meem, noj 0.59 μL ntawm cov tshuaj hauv Tshuag thiab ntxiv rau 1 mL ntawm kab lis kev cai nruab nrab.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Dissolve maj mam: Tsis txhob swirling lossis ua nruj ua tsiv; maj mam tig kom yaj.

Cov txheej txheem nruj aseptic: Kev ua haujlwm yog ua nyob rau hauv lub laminar flow hood, siv cov khoom siv tsis muaj menyuam.

Ua tiav kev tiv thaiv los ntawm lub teeb: Sensitive rau lub teeb, txhua kauj ruam yuav tsum tau ua nyob rau hauv lub teeb - tiv thaiv tej yam kev mob.

Npaj thiab siv tam sim ntawd: Kev ruaj ntseg yog txwv tom qab hloov kho, yog li nws raug pom zoo kom siv sai li sai tau.

Kom tsis txhob adsorption: Dilute nrog cov tshuaj uas muaj 0.1% bovine serum albumin los yog silanized qis -cov hlab adsorption.

2. Cia tej yam kev mob:

Unreconstituted lyophilized hmoov:

Ntev - lub sij hawm cia: Frozen ntawm -20 degree, txee lub neej 24 lub hlis

Kev cia zoo: -80℃(ntub khov), txee lub neej 36 lub hlis.

Kev tiv thaiv nruj ntawm lub teeb: Yuav tsum muab khaws cia rau hauv lub teeb qub- pov thawj aluminium foil hnab.

Kev tiv thaiv noo noo: Khaws qhuav, nrog ua -hauv desiccant.

Reconstituted daws:

tam sim ntawdtom qab kev kho dua tshiab rau kev ua haujlwm zoo.

Short - lub sij hawm cia: Txias ntawm 2-8 degree, deb ntawm lub teeb, tsis pub ntau tshaj 8 teev.

Repackage thiab khov: Khaws ntawm -20℃lossis -80℃deb ntawm lub teeb, tsis pub ntau tshaj 1 lub lis piam.

Rov qab khov-thaw cycles raug txwv nruj heev: qhov siab tshaj plaws ntawm ib qho khov -thaw voj voog.

Kev thauj mus los:

Txias- cov hmoov qhuav: thauj nrog dej khov qhuav (-78 degree)

Luv - lub sij hawm shipping: Thauj nrog cov pob khov nab kuab ntawm 2-8 degree, xyuas kom tus me nyuam tsis pub dhau 48 teev.

Ntim: Lub teeb- pov thawj aluminium foil hnab + lub tshuab nqus tsev foob + ua npuas ncauj insulated lub thawv

3. Kev ruaj ntseg thiab cov qauv ua tiav:

Tshuaj thiab lub cev stability:

Nws yog qhov ruaj khov nyob rau hauv aqueous daws nrog pH ntau ntawm 5.0-7.0.

Tsis txhob sib cuag nrog cov kua qaub uas muaj zog, muaj zog alkalis, thiab oxidizing tus neeg sawv cev.

rhiab heev rau cov neeg kho tshuab kev nyuaj siab (xws li ua nruj ua tsiv los yog vortexing).

Kev kho ntawm bioactivity:

Kev xa tawm kom raug thiab khaws cia ntawm -80℃yog qhov tseem ceeb rau kev tswj xyuas kev ua haujlwm mus ntev.

Thaw thiab faib cov tshuaj maj mam rau ntawm cov dej khov ua ntej siv.

Xav taudab tsi, thov hu raupeb

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