Cagrilintide 5mg / lub raj mis qhia
Pharmaceutical-qib ntev- ua yeeb yam amylin analogue|Ua nyob rau hauv Suav teb amylin receptor agonist 5mg / vial
Hom npe: Cagrilintide hmoov
Kev tshawb fawb thiab kev loj hlob codeib: 833
Hom qauv: Acylated peptide raws li natural amylin sequence optimization
Hom phiajTom ntej: Amylin receptor (AMYR)
Purity: Ntau dua lossis sib npaug li 99.0% (HPLC kuaj pom)
Qhov tshwm sim: Dawb lyophilized hmoov
Cia: Khaws khov ntawm -20℃deb ntawm lub teeb; Tom qab thawing, refrigerate ntawm 2-8 degrees.
Core zoo thiab muaj nuj nqi
Cagrilintide yog ibntev - ua yeeb yam amylin receptor agonist tsim los ntawm cov qauv zoo molecular ntawm ntuj amylin, thiab yogtus neeg sawv cev tseem ceeb ntawm cov tiam tom ntej ntawm cov tshuaj tswj qhov hnyav. Los ntawmtshwj xeeb ua kom cov amylin receptor, nws ua kom muaj zog qab los noj mov, qeeb plab hnyuv tawm, thiab kev tswj qhov hnyav.nyob rau hauv lub hauv paus paj hlwb thiab peripheral cov ntaub so ntswg. Nws tau ua tau zoo kawg nkausCov teebmeem poob phaus thiab kev txhim kho metabolic muaj peev xwm hauv kev tshawb fawb txog kev rog, ntshav qab zib hom 2, thiab lwm yam metabolic syndromes, uaib qho cuab yeej tseem ceeb molecule rau kev tshawb fawb txog kev tswj qhov hnyav thiab kev txhim kho cov tshuaj rau cov kab mob metabolic.
✅ PreciseMechanism ntawm Action:
Central qab los noj mov: Ua rauLub arcuate nucleus thiab parabrachial nucleus ntawm lub hypothalamus thiab lub nucleus ntawm ib leeg nyob rau hauv lub hlwb, ua kom muaj zog thiab kav ntev ntawm satiety los ntawm activating amylin receptors.
Peripheral metabolic kev cai:
Qhov tseem ceebslows gastric emptying tus nqithiab ncua sij hawm cov zaub mov nyob hauv plab.
Inhibitspostprandial glucagon secretionthiab txhim kho kev tswj ntshav qab zib
me ntsisnce kev siv hluav taws xobthiab txhawb qhov "browning" ntawm cov ntaub so ntswg adipose dawb.
Ntev -ua yeeb yam tshuaj pharmacokinetic : Hloov khonrog fatty acid side chains ho prolongs ib nrab -lub neej, txhawbib zaug -ib lub lim tiamdosing regimen.
Receptor xaiv: Nws muaj kev sib raug zoo siab thiab kev xaiv rau amylin receptor, tsis txhob muaj kev pheej hmoo ntawm cross-reactivity nrog calcitonin receptor.
✅Qualityqhov zoo ntawm Suav manufacturers:
Advanced synthetic modification techniques:
Los ntawm kev ua haujlwmsolid-theem peptide synthesis ua ke nrog proprietary fatty acid sab- chain targeted modification technology, qhov kev hloov kho efficiency ntau dua los yog sib npaug li 95%.
Ua kom zooCov tshuaj tiv thaiv acylationxyuas kom meej kev sib txuas ntawm C18 diacid fatty acid chains.
Tag nrho cov synthesis yield ntau dua los yog sib npaug rau 80%, nrog loj - nplai ntau lawm ncav cuag qib kilogram.
Multidimensional purification thiab zoo tswj system:
Plaub -theem purification txheej txheem: ion pauv → hydrophobic chromatography → molecular sieve → thim rov qab -theem HPLC
Purity tswj: RP-HPLC purity Ntau dua lossis sib npaug li 99.0%, SEC-HPLC monomer cov ntsiab lus Ntau dua lossis sib npaug rau 98.5%.
Cov qauv kev pom zoo:
Kev txiav txim siab ntawm qhov hnyav molecular los ntawm huab hwm coj spectrometry (MS)
Nuclear magnetic resonance (NMR) pov thawj ntawm fatty acid chain linkage sites
Circular dichroism (CD) tsom xam ntawm theem nrab qauv stability
Qhov tseem ceeb impurity tswj:
Muaj feem xyuam peptide impurities: tshem tawm ib ntus, oxidation khoom, deamidation khoom
Txheej txheem impurities: fatty acid saw residues, organic solvent residues
Kev txheeb xyuas bioactivity:
Hauv vitro receptor binding assay: Kev txiav txim siab ntawm affinity (KD tus nqi) rau amylin receptor.
Kev sim ua haujlwm cAMP: Txheeb xyuas receptor agonistic ua haujlwm (EC50 tus nqi)
Nyob rau hauv vivo pharmacodynamic qauv: Kev lees paub qhov hnyav poob los ntawm kev noj zaub mov -induced rog (DIO) tsiaj qauv.
Kev kawm ruaj khov:
Ua kom nrawm nrawm ntsuas (40℃/ 75% RH, 6 lub hlis).
Ntev - cov ntaub ntawv ruaj khov (-20℃, 24 lub hlis)
Lub teeb stability thiab kub cycling test
✅ khoomNta:
Siab muaj zog thiab ntev - cov nyhuv kav ntev: Ib koob tshuaj tuaj yeem ua rau muaj kev qab los noj mov -txo cov nyhuv uas kav ntev txog ib lub lis piam.
Kev xaiv siab: Superior selectivity rau amylin receptors piv rau ntuj amylin
Zoo kev nyab xeeb profile: Cov kev tshawb fawb soj ntsuam tau pom tias muaj kev nyab xeeb zoo thiab kev zam.
Synergistic muaj peev xwm: Nws muaj kev sib koom ua ke nrog GLP-1 receptor agonists, ua kom muaj txiaj ntsig zoo.
Daim ntawv qhia kev siv thiab cia
1. Kev kho dua tshiab thiab kev npaj:
Cov kuab tshuaj tshwj xeeb:
Cov sterile reconstitution nrog rau diluent(pH 7.4-8.0 tsis) yuav tsum tau siv.
Kev siv ntawmsaline zoo tib yam, dej tsis muaj menyuam rau kev txhaj tshuaj, lossis lwm yam uas tsis yog - cov kuab tshuaj tshwj xeeb raug txwv nruj heev.
Tus txheej txheem npaj:
Maj mam txhaj 1.0 mL ntawm qhov tshwj xeeb diluent raws phab ntsa sab hauv ntawm lub vial.
Maj mam tiglub vial horizontally hauv koj xib teg rau 2-3 feeb.
Ib qho ntshiab los yog me ntsis opalescent tovtau txais ntawm 5 mg / mL.
Ua qhov thib ob dilution nrog tib lub diluent lossis physiological saline uas muaj 0.1% BSA.
Cov ntsiab lus tseem ceeb kom nco ntsoov:
Tsis txhob ua nruj ua tsiv thiab vortexing thaum lub sij hawm dissolving txheej txheem.
Cov tshuaj reconstituted yuav tsum tau sivhauv 1 teev.
Ua ntej kev tswj hwm, pom qhov muag tshuaj xyuas cov tshuaj kom paub meej thiab tsis muaj cov khoom.
2. Cia tej yam kev mob:
Unreconstituted lyophilized hmoov:
Khaws khov ntawm -20 degree, txee lub neej24 hli.
Khaws khov ntawm -80 degree; txee lub neej36 muaj.
Tsis txhob rov khov dua -thaw cycles
Reconstituted tshuaj daws:
rau 24 teevthaum lub tub yees ntawm 2-8 degree.
Tsis txhob khov.
Kev thauj mus los:
Kev thauj dej khov qhuav (hauv qab -78 degree)
Vacuum Insulated Ntim
Nruab nrog ntsuas kub ntsuas
3. Kev tshawb fawb thiab kev npaj ua ntawv thov:
Preclinical tsiaj kev tshawb fawb:
Core qauv:
Khoom noj khoom haus-induced rog (DIO) nas/rat qauv
Zucker rog rog qauv
Ib tus qauv ntawm cov kab mob metabolic tshwm sim los ntawm kev noj zaub mov muaj roj ntau -
Dosage regimen:
Kev txhaj tshuaj subcutaneous0.1-1.0 mg / kg, 1-2 zaug hauv ib lub lis piam.
Intraperitoneal txhaj tshuaj0.5-2.0 mg / kg, 1-2 zaug hauv ib lub lis piam.
Txoj kev kho mob:
luv- lub sij hawm ua tau zoo: 4-8 lub lis piam
Ntev -kev ua tau zoo: 12-24 lub lis piam
Kev ntsuas ntsuas:
Qhov hnyav, noj zaub mov, lub cev muaj pes tsawg leeg
Ntshav qab zib, insulin, ntshav lipids
Kev siv hluav taws xob, kev ua pa tawm
Mechanism ntawm kev kawm ua:
Receptor occupancy thiab signaling pathways
Central appetite tswj Circuit Court
Peripheral metabolic kev tswj mechanism
Synergistic nyhuv nrog lwm cov tshuaj metabolic
4. Cov tswv yim tsim kev sim:
Kev tshawb nrhiav tshuaj: Teem 3-4 koob tshuaj gradients
Tswj pab pawg teeb tsa:
Solvent tswj pawg
Pawg tswj qhov zoo (piv txwv li, liraglutide)
Kev sib xyaw ua ke pab pawg (ua ke nrog GLP-1RA)
Lub sijhawm soj ntsuam cov ntsiab lus: Dynamic saib xyuas ntawm ntau lub sijhawm
Vim li cas thiaj xaiv Cagrilintide ua hauv Suav teb?
Technicalqhov zoo:
Mastering core fatty acid side chain modification technology
Muaj txoj cai ywj pheej ywj pheej kiag li
Kev ua tiav thev naus laus zis platform los ntawm R & D mus rau ntau lawm
Cov chaw tsim khoom ua tau raws li cov qauv cGMP thoob ntiaj teb
Zoolav:
Purity Ntau dua lossis sib npaug li 99.0%, ib qho impurities Tsawg dua lossis sib npaug li 0.5%
Batch sib xws RSD <5%
Ua kom tiav cov ntaub ntawv kawm zoo
Kev kawm zoo sib piv nrog cov tshuaj thawj
Daim ntawv thovTxhawb nqa:
Muab cov lus qhia ntxaws ntxaws
Kev sim tsim kev txhawb nqa
Kev pabcuam cov ntaub ntawv
Cov kev pabcuam customized
Nqiqhov zoo:
Loj -scale ntau lawm txo nqi
Piv nrog rau cov khoom siv txawv teb chaws, lawv muaj tus nqi meej.
Cov khoom ruaj khov thiab xa khoom raws sijhawm
Flexible ntim specifications
Tshawb nrhiav thiab siv cov lus qhia
Kev tshawb nrhiav kev rog:
Kev noj qab haus huv tswj mechanism
Cov tswv yim tswj qhov hnyav
Kev tswj hwm lub zog metabolism
Txhim kho lub cev muaj pes tsawg leeg
Cov kab mob metabolic:
Mob ntshav qab zib hom 2
Metabolic Syndrome
Nonalcoholic fatty siab kab mob
Cardiovascular metabolic txaus ntshai
Kev kho mob ua ke:
Synergistic nyhuv nrog GLP-1RA
Kev sib xyaw ua ke nrog lwm cov tshuaj tiv thaiv metabolic
Tsau - kev txhim kho koob tshuaj ua ke
Kev npaj kho tus kheej
Cov tshuaj txhais lus:
Kev soj ntsuam kev nyab xeeb Preclinical
Kev tshawb fawb Pharmacokinetic
Tshawb nrhiav qhov pom kev noj tshuaj kom zoo
Biomarker nrhiav pom
Preclinical kev tshawb fawb cov ntaub ntawv siv
Pharmacodynamic cov ntaub ntawv:
Cov nyhuv poob phaus: Hauv cov qauv DIO, koob tshuaj 0.3-1.0 mg/kg tuaj yeem tsim cov koob tshuaj raws li qhov hnyav.
Pub kev tiv thaiv: txo qis kev noj zaub mov 24-teev.
Kev txhim kho metabolic: Txhim kho insulin rhiab heev, txo cov ntshav qabzib ceev
Kev nyab xeeb: Lub qhov rais kho dav dav, tsis muaj cov tshuaj lom neeg pom tseeb.
Pharmacokinetics:
Ib nrab-lub neej: Kwv yees li 120 teev
Bioavailability: Ntau dua lossis sib npaug li 85% rau kev txhaj tshuaj subcutaneous
Volume ntawm kev faib tawm: Siab binding tus nqi rau plasma proteins
Clearance: los ntawm peptidase degradation thiab lub raum excretion
Cov ntsiab lus
Cagrilintide,ib tiam tshiab ntawm ntev - ua yeeb yam amylin receptor agonists, tuav tus nqi tseem ceeb scientific thiab cog lus kev siv tshuaj kho mob hauvtswj qhov hnyav thiab kho cov kab mob metabolic. Tuam Tshoj tuam ntxhab, dhau los ntawm cov khoom siv hluav taws xob hloov kho siab heev, kev tswj xyuas nruj, thiab cov ntaub ntawv tshawb fawb dav dav, muab cov kws tshawb fawb thoob ntiaj teb nrogsiab -cov cuab yeej tshawb fawb zoo heev. Lub zog, ntev - ua yeeb yam thiab kev nyab xeeb profilentawm cov khoom no muaj kev txhawb zog rau kev tshawb fawb thiab kev tsim tshuaj hauv kev rog rog thiab cov kab mob metabolic.
Xav taudab tsi, thov hu raupeb
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Cim npe nrov: cagrilintide 5mg / vial zoo suppresses qab los noj mov thiab nce zog siv, Tuam Tshoj cagrilintide 5mg / vial zoo suppresses qab los noj mov thiab nce zog siv nyiaj txiag manufacturers, lwm tus neeg, Hoobkas
