Botox 100iu / vial Tau txais kev nyab xeeb thiab siv tau zoo nkauj thiab kho

Botox Hom A 100 IU / vial: Cov yam ntxwv tseem ceeb

Botulinum toxin type A neurotoxin complex|Neuromuscular hlws ris thaiv cov protein 100 IU / lub raj mis

Cov khoom xyaw nquagTom ntej: Botulinum Toxin Hom A

Qhov chaw: Purified los ntawm fermentation ntawm Clostridium botulinum

Molecular hnyav: Kwv yees li 150 kDa

Purity: Ntau dua lossis sib npaug rau 99.5% (SDS-PAGE)

Cov haujlwm tshwj xeeb: Ntau dua lossis sib npaug li 100 IU / vial

Qhov tshwm sim: Dawb khov- ncuav mog qab zib qhuav los yog hmoov

Cia: khov ntawm -20 degree, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw qhuav.

Daim ntawv qhia kev siv thiab cia

Botox hom A neurotoxin:

Botulinum toxin type A yog ib qho muaj zog heev neurotoxin uas irreversibly thaiv kev tso tawm ntawm acetylcholine los ntawm tshwj xeeb cleaving SNAP -25 protein ntawm paj hlwb, ua rau cov tshuaj denervation thiab ib ntus tuag tes tuag taw ntawm lub hom phiaj cov leeg. Tsis zoo li peptides lossis cov tshuaj hormones, nws cov teebmeem yog qhov tseeb, kav ntev, thiab tshwj xeeb heev. Nws qhov tshwj xeeb neuromuscular hlws ris thaiv cov txheej txheem ua rau nws tsis tuaj yeem hloov pauv hauv cov haujlwm tseem ceeb hauv neurobiological xws li cov leeg nqaij, autonomic hyperactivity, mob teeb liab hloov, thiab tso tawm neurotransmitter. Nws kuj yog ib qho cuab yeej tseem ceeb rau kev kawm txog kev ua haujlwm ntawm lub ntsej muag qhia cov leeg, cov leeg pob txha, thiab cov leeg du.

Vim nws pom tau tias muaj zog neuromuscular thaiv cov nyhuv thiab cov kev ua haujlwm hauv zos, botulinum toxin type A yog qhov kev xaiv zoo tshaj plaws rau ntau tus kws tshawb fawb hauv neuroscience, kev tawm dag zog lub cev, thiab kev tshawb fawb mob. Nws tsis ua los ntawm cov txheej txheem metabolic lossis txoj hauv kev hormonal, tab sis qhov tseeb yog lub hom phiaj ntawm cov paj hlwb cholinergic, tsis txhob muaj kev mob tshwm sim thoob plaws. Nws tswj tau, koob tshuaj - nyob ntawm cov leeg nqaij hauv zos so thiab glandular secretion inhibition ua rau nws yog ib qho kev tshawb fawb tseem ceeb thiab muaj nuj nqis hauv cov tsiaj ua qauv ntawm hyperactivity syndrome, mob neuropathic, hyperhidrosis, thiab lwm yam kab mob.

Kev siv Botox hom A:

Nws tshwj xeeb cleaves SNAP-25 protein ntawm cov hlab ntsha xaus, irreversibly thaiv kev tso tawm ntawm acetylcholine, ua rau chemical denervation thiab ib ntus so ntawm lub hom phiaj cov leeg. Botulinum toxin type A yog ib qho zoo heev neuromodulator raws li cov txheej txheem molecular meej thiab yog cov txheej txheem kub rau kev kawm neuromuscular thiab autonomic paj hlwb muaj nuj nqi.

Botulinum toxin type A yog siv dav hauv cov neuroscience, kev tawm dag zog lub cev, tshuaj kho mob, thiab kev tshawb fawb txog cov txheej txheem pathological ntawm cov kab mob ntsig txog. Nws zoo -txhais lub hom phiaj thiab tswj tau cov tshuaj pharmacological muab lub qhov rai tshawb fawb tshwj xeeb rau kev tshawb nrhiav lub cev ntawm cov kab mob neuromuscular hlws ris, cov kab mob ntawm cov leeg nqaij, cov qog nqaij hlav txawv txav, thiab cov txheej txheem ntawm kev mob ntev. Nws tseem yog ib qho tseem ceeb hauv kev ntsuam xyuas cov tshuaj antispasmodic tshiab thiab kawm txog cov nqaij ntshiv thiab cov paj hlwb.

Txoj kev siv thiab khaws cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj pom zoo:

Tsuas yog cov kuab tshuaj tau teev tsegyognrog rau tsis muaj menyuam, preservative -dawb physiological saline (0.9% NaCl).

Txwv tsis pub kiag li: Kev siv cov tshuaj tua kab mob - muaj cov ntsev, cov dej tsis huv rau kev txhaj tshuaj, lactated Ringer's tov los yog lwm yam tshuaj uas tsis tau teev tseg yog txwv tsis pub., raws li nws yuav ua rau kom cov co toxins inactivation, aggregation los yog unpredictable lom lom.

Tus txheej txheem npaj:

Solvent npaj:

Tshem tawm cov kua qaub uas muaj kuab lom los ntawm lub tub yees (2-8 degree) thiab cia nws sawv ntsug kom txog thaum nws ncav cuag chav sov.

Tag nrho cov txheej txheem tau ua raws li nruj raws li cov hauv paus ntsiab lus aseptic thiab nyob rau hauv lub txee biosafety.

Reconstitution txheej txheem:

Ntxiv cov ntim tau teev tseg (piv txwv li, 1.0 mL, 2.0 mL, lossis 4.0 mL) ntawm cov tshuaj uas tsis muaj tshuaj saline rau 100 IU vial.

Nrog rab koob tig mus rau hauv qab, maj mam txhaj cov kuab tshuaj raws lub raj mis phab ntsa kom tsis txhob cuam tshuam ncaj qha rau lub khov- ncuav mog qab zib qhuav thiab tsim ua npuas npuas.

Maj mam tiglub vial horizontally nyob rau hauv xib-teg ntawm koj txhais tes, tsis muaj co los yog agitating, kom txog rau thaum cov lyophilized tshuaj yog yaj tag thiab cov tshuaj yog ntshiab thiab tsis muaj xim.

Kev npaj siab yuav tsum tau npaj: txiav txim siab raws li kev sim (piv txwv li, ntxiv 2.0 mL ntawm cov kuab tshuaj kom tau txais 50 IU / mL daws).

Repackaging thiab siv:

Qhov kev daws teeb meem yuav tsum tau uasiv tam sim ntawd. Yog tias luv luv - lub sijhawm cia yog tsim nyog, nws yuav tsum muab tso rau hauv lub tub yees ntawm 2-8℃thiab siv li ntawm 4 teev.

Tsis txhob repackage thiab khov reconstituted daws.

Ua hauj lwm concentration/dosage reference:

Tsiaj kev sim (kev txhaj tshuaj intramuscular hauv zos): Qhov ntau npaum li cas yuav tsum tau muab xam raws li cov tsiaj hom, qhov hnyav, lub hom phiaj ntawm cov leeg nqaij thiab lub hom phiaj ntawm kev sim, thiab feem ntau yog nyob rau hauv ntau yam.0.5-5 IU / kg. Nws yuav tsum tau txiav txim siab los ntawm kev sim ua ntej.

Kev sim hauv vitro cell: Thaum siv los kawm txog cov txheej txheem ntawm kev tso tawm neurotransmitter, tsis tshua muaj siab (feem ntau nyob rau hauv pM mus rau nM ntau) yuav tsum tau siv raws li kev qhia ua haujlwm.

Lus Cim Tseem Ceeb: Botulinum toxin yog qhov muaj zog heev, nrog rau cov koob tshuaj ntau heev - teb nkhaus.Kev suav tshuaj noj thiab kev tswj hwm yuav tsum tau ua los ntawm cov neeg ua haujlwm tau txais kev cob qhia.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Solvent exclusivity: Tsuas yog cov khoom siv tsis muaj menyuam, cov tshuaj tua kab mob -dawb physiological saline tov yuav tsum tau siv.

Txoj kev daws teeb meem: Dissolve tsuas yog maj mam tig horizontally. Ib qho kev ua haujlwm hnyav tuaj yeem ua rau cov protein denaturation thiab tsis ua haujlwm.

Cov txheej txheem aseptic: Yuav tsum tau ua nyob rau hauv lub biosafety txee, siv sterile syringes, koob thiab consumables.

Saib xyuas qhov kev daws teeb meem: Tom qab kev kho dua tshiab, nws yuav tsum yog qhov pom tseeb, tsis muaj xim tsis muaj cov khoom pom. Yog tias nws dhau los ua huab, tsis muaj xim, lossis muaj cov khoom, nws yuav tsum muab pov tseg.

Npaj -rau- siv: Kev ruaj ntseg poob qis heev tom qab hloov kho, thiabyuav tsum tau siv tam sim ntawdlos yog nyob rau hauv ib lub sij hawm luv luv.

2. Cia tej yam kev mob:

Unreconstituted lyophilized hmoov:

Ntev - lub sij hawm cia: Khaws khov ntawm -20 degree, txee lub neej 24 lub hlis (raws li daim ntawv lo khoom).

Kev cia zoo: Khaws ntawm -80℃rau kev ruaj ntseg ntxiv.

Kev tiv thaiv nruj ntawm lub teeb: Yuav tsum muab khaws cia rau hauv lub teeb qub- pov thawj lub thawv sab nraud.

Khawsqhuav.

Reconstituted daws:

Siv tam sim ntawd: Nws yuav tsum tau siv tam sim ntawd tom qab kev kho dua tshiab rau kev ua haujlwm zoo.

Short - lub sij hawm cia: Yog tias tsis siv tam sim ntawd, nws tuaj yeem tso rau hauv tub yees ntawm 2-8 degree,tab sis yuav tsum tau siv tsis pub dhau 4 teev.

Kev khov yog txwv nruj heev: Reconstituted daws yuav tsum tsis txhob khov, raws li khov yuav ua kom puas tag nrho lawv cov qauv thiab ua rau inactivation mus tas li.

Kev thauj mus los:

Kev thauj mus los txias: Yuav tsumraug thauj nyob rau hauv cov dej khov qhuav (-78 degree) lossis qis dua -20 degree.

Ntim: Lub teeb- pov thawj lub thawv + lub tshuab nqus tsev foob + siab- lub zog insulated lub thawv + ntsuas kub.

3. Kev ruaj ntseg, kev nyab xeeb, thiab cov txheej txheem tuav:

ruaj khov:

Nws yog rhiab heev rau kub, pH thiab mechanical shear force.

Nws yog qhov ruaj khov nyob rau hauv ib puag ncig pH ntawm sterile saline, tab sis nws tseem yuav degrade sai sai tom qab dissolution.

Biosafety:

Biohazard qib: Botulinum toxin yogib tug siab -kev pheej hmoo lom neeg, thiab nws tuav yuav tsum ua raws li lub teb chaws txoj cai ntawm biosafety kev tswj ntawm lub chaw soj nstuam tuav cov kab mob pathogenic heev.

Cov cuab yeej tiv thaiv tus kheej: Cov neeg ua haujlwm yuav tsum hnav khaub ncaws tiv thaiv, hnab looj tes, tsom iav thiab qhov ncauj qhov ntswg, thiab kev ua haujlwm yuav tsum tau ua nyob rau hauv lub txee biosafety qib 2 (BSC-II).

Kev pov tseg pov tseg: Tag nrho cov khoom siv hluav taws xob thiab cov kev daws teeb meem ntxiv uas tau los rau hauv cov co toxins yuav tsum tau tsau rau hauv qhov siab -concentration chlorine- muaj cov tshuaj tua kab mob (xws li 1% sodium hypochlorite) tsawg kawg 30 feeb, thiab tom qab ntawd raug rau siab -siab kom tsis muaj menyuam.

Teb ceev xwm ceev: Tsim thiab paub txog cov phiaj xwm xwm txheej kub ntxhov rau cov dej xau thiab cov neeg ua haujlwm raug. Cov chaw kuaj mob yuav tsum khaws cov tshuaj tiv thaiv kab mob hauv cov ntshav kom yooj yim.

Xav taudab tsi, thov hu raupeb

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