Alprostadil 20mcg / vial * 5 Txhim kho erectile muaj nuj nqi

Alprostadil 20mcg/vial (5 vials) - Kev Taw Qhia Core*

Pharmaceutical qib prostaglandin E1|Ua nyob rau hauv Suav teb, vasoactive tshuaj 20mcg / vial 5*

Lub npeTom ntej: Prostaglandin E1

CAS Nr.: 745-65-3

Tshuaj npe: (1R,2R,3R)-3-hydroxy-2-[(E)-(3S)-3-hydroxy-1-octenyl]-5-oxocyclopentaneheptanoic acid

Cov mis mos molecular: C20H34O5

Molecular hnyav: 354.48

Specifications20 micrograms / vial, 5 vials / thawv

Qhov tshwm sim: Dawb khov- cov pob zeb qhuav los yog hmoov

Cia: Khaws rau hauv lub tub yees ntawm 2-8 degree, deb ntawm lub teeb.

Core zoo thiab muaj nuj nqi

Alprostadil yog ibSynthetic analogue ntawm natural prostaglandin E1 (PGE1)thiabib yam khoom tseem ceeb rau kev tshawb fawb vasoactivity. Los ntawm ntau yam mechanisms, suav nrogncaj qha so ntawm vascular du nqaij, inhibition ntawm platelet aggregation, txhim kho erythrocyte deformability, thiab tiv thaiv vascular endothelium,nws muajclassic thiab tseem ceeb daim ntaub ntawv nyob rau hauv vascular physiology, kab mob plawv, erectile kawg, peripheral vascular kab mob, thiab neonatal patent ductus arteriosus.Nws yogib tug tseem ceeb cuab yeej tshuaj rau vascular biology thiab microcirculation kev tshawb fawb.

✅CoreMechanism ntawm Action:

Vasodilation: Activates adenylate cyclase, tsub kom intracellular cAMP theem, thiab relaxes vascular du nqaij.

Antiplatelet aggregation: Inhibits platelet activation thiab aggregation, tiv thaiv thrombosis.

Cell tiv thaiv: Stabilizes cell membranes, txo cov dawb radical ntau lawm, thiab tiv thaiv cov ntaub so ntswg ischemic.

Txhim kho cov ntshav khiav: Zoo heev txhim kho microcirculation thiab ua kom cov ntaub so ntswg perfusion.

Kev tiv thaiv kab mob: Tswj kev tso tawm ntawm cov kab mob inflammatory thiab txo cov inflammatory teb.

Kev ua haujlwm erectile: Vasodilation ntawm lub corpora cavernosa txhawb nqa penile erection.

✅Qualityqhov zoo ntawm Suav manufacturers:

Synthesis txheej txheem: Asymmetric synthesis technology yog siv, nrog kev tswj nruj ntawm chiral chaw zov me nyuam, ua tiav qhov kho qhov muag purity ntawm Ntau dua lossis sib npaug rau 99.5%.

Formulation technology: Kev siv ntawmliposome tshuaj muab technologyho txhim kho tshuaj stability thiab lub hom phiaj.

Qhov system zoo: Ua raws li Suav Pharmacopoeia (ChP) thiab European Pharmacopoeia (EP) cov qauv.

Purity tswj:

Cov ntsiab lus tseem ceeb: 90.0% -110.0%

Yam khoom: Ib qho impurities Tsawg dua lossis sib npaug li 0.5%, tag nrho impurities Tsawg dua lossis sib npaug li 1.5%

Isomer tswj: nruj me ntsis tswj cov ntsiab lus ntawm 8-isomer

Bioequivalence: Nyob rau hauv vitro dissolution thiab pharmacodynamic tsis zoo ib yam li cov thawj tshuaj.

Kev tshawb fawb txog kev ruaj ntseg: Ua kom tiav ntev - lub sij hawm ruaj khov (24 lub hlis) thiab kev ntsuas nrawm nrawm (6 lub hlis).

✅ khoomNta:

Liposphere formulations: txhim kho tshuaj stability thiab txo qhov khaus.

Lub hom phiaj xa khoom: xaiv tsub zuj zuj nyob rau hauv cov kab mob vascular cheeb tsam

Ntxiv ib nrab -lub neej: los ntawm 5-10 feeb rau cov qauv qauv rau 30-60 feeb.

Txhim kho qhov kam rau ua: Cov tshuaj txo qis hauv zos xws li phlebitis.

Daim ntawv qhia kev siv thiab cia

1. Kev kho dua tshiab thiab kev npaj:

Cov kuab tshuaj tshwj xeeb:

Cov khoom siv tshwj xeeb hnyav hnyav(feem ntau yog sterile saline los yog cov tshuaj tsis muaj tshuaj stabilizer) yuav tsum tau siv.

Cov kuab tshuaj uas muaj benzyl cawv lossis lwm yam tshuaj tua kab mob raug txwv nruj heev.

Tus txheej txheem npaj:

Txhaj 1 ml ntawm cov kuab tshuaj tshwj xeeb raws lub raj mis phab ntsa

Maj mam tig kom txog thaum yaj tag; tsis txhob tshee hnyo.

Ib qho kev daws teeb meem meej nrog qhov concentration ntawm 20 mcg / ml tau txais.

Ntxiv dilution nrog physiological saline raws li xav tau rau kev sim.

Cov ntsiab lus tseem ceeb kom nco ntsoov:

Sivhauv 2 teevtom qab yaj.

Tsis txhob sib cuag nrog cov ntim yas ntev

Tsis txhob sib xyaw nrog lwm cov tshuaj hauv tib lub thawv

Tsis txhob siv yog hais tias cov tshuaj ua pos huab, tsim ib tug precipitate, los yog hloov xim.

2. Cia tej yam kev mob:

Tsis qhib:

Txias ntawm 2-8℃thiab khaws cia rau hauv cov ntim khoom qub kom deb ntawm lub teeb.

Lub sijhawm siv tau:24 hli

Kev khov yog txwv nruj heev.

Rov tsim dua:

Tom qab kev npaj, nws yuav tsum tau khaws cia ntawm 2-8 degree.

Yuav tsum tau sivhauv 2 teev

Tsis txhob siv ntau zaus

Kev thauj mus los:

2-8℃txias saw tsheb thauj mus los

Zam kev hloov pauv kub heev

Tsis txhob khov

Kev xav txog kev ruaj ntseg:

Nws yog rhiab heev rau lub teeb thiab yuav tsum tau ua nyob rau hauv tag nrho tsaus ntuj nti.

rhiab heev rau qhov kub thiab txias, tsis txhob kub siab.

Stable nyob rau hauv pH ntau ntawm 6.0-8.0

Vim li cas thiaj xaiv Alprostadil, ua hauv Suav teb?

Technicalqhov zoo:

Mastering cov tub ntxhais lipid microsphere npaj technology

Stabilizer formula nrog ywj siab tswv cuab txoj cai

Advanced asymmetric synthesis txheej txheem

Ib qho kev tswj xyuas zoo

Zoolav:

Ua tau raws li cov qauv hauv tsev thiab thoob ntiaj teb cov tshuaj pharmacopoeia

nruj impurity tswj

High batch sib xws

Ua kom tiav cov ntaub ntawv tshawb fawb zoo

Cov ntsiab lus

Alprostadil, ibclassic prostaglandin tshuaj, tuav tus nqi irreplaceablehauv vascular biology thiab kev tshawb fawb preclinical. Tuam Tshoj cov tuam txhab, dhau los ntawm cov txheej txheem tsim khoom, kev tswj xyuas zoo, thiab kev tsim kho tshiab thiab kev txhim kho, muab cov kws tshawb fawb nrogsiab -cov cuab yeej tshawb fawb zoo, ruaj khov heev. Nwsntau yam teebmeem pharmacological thiab txhim khu kev qha kev ruaj ntseg profileua kom nws yog ib qho kev xaiv tseem ceeb rau kev tshawb fawb txog vascular-cov kab mob ntsig txog.

Xav taudab tsi, thov hu raupeb

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