Hauj lwm lawm

Kev tsis

GW0742 (GW-0742) Raw Khoom Hmoov Core Taw Qhia

Kev Tshawb Nrhiav {{{}} qib cov khoom siv tau|GW0742 (GW-0742) PARP / Δ AGONIST

Tshuaj lom neeg npe: (2-Methyl-4 - ((4-Methyl-2- (4-trifluorrphenyl) -1,3-thiazol-5-yl) methylthio) penoxy) acetic acid

Tus lej: 317318-84-6

Molecular cov mis: c₂₁h₁₈f₃no₃s₂

Molecular hnyav: 453.50

Melting Taw tes: 145-148 Qib

Zog: Dawb rau tawm ntawm -} e} crystalline hmoov

Purity: ntau dua los yog sib npaug rau 98% (HPLC)

Cov teebmeem tseem ceeb

GW0742 yog aMuaj kev xaiv PARP / Δ AgronistCov. Vim nwsZoo heev fatty acid oxidation thiab cov kev cai metabolic, nws yog dav sivHauv Kev Tshawb Fawb Kab Mob Kab Mob Kev Tshawb Fawb, Kev Siv Kev Ua Haujlwm Kev Nyab Xeeb Kev Ua Haujlwm Kev Kawm Ntxiv, thiab Kev Tiv Thaiv Kev Tiv Thaiv Kev Tawm Tsam Kev Tshawb Fawb.

✅ Ua kom muaj roj ua roj acid oxidation:

Ua kom lub PPP / Δ txoj kevthiab txhim kho kom tau cov roj acid - qhov muaj peev xwm

Cov ntshav qis lipidthiab txo cov roj ntsha ua paug

✅ Kev Ua Kom Zoo Siab Kev Ua Haujlwm:

Nce mitochondrial biogenesisthiab txhim kho aerobic thev naus laus zis los ntawm 30-50%

Txo lactic acid zuj zusthiab ncua kev tawm dag zog qaug zog

✅ Kev Tiv Thaiv Kev Tiv Thaiv Cardiovascular:

Txhim kho cov vascular endothelial muaj nuj nqithiab txo qhov kev pheej hmoo ntawm atherosclerosis

Anti -} mob thiab mob antioxidant, tiv thaiv myocardial cell

GW0742 (GW-0742) NTA

Muaj kev xaiv siab heev:

PARp / δ Epriendity: 1000-fold ntau dua PARP thiab PARP

Tshwj xeeb tshaj plawsLub hom phiaj gene qhia nrog cov kev pheej hmoo ntawm cov kev mob tshwm sim

Qhov ncauj muaj txiaj ntsig:

Siab qhov ncauj bioavailability(>80%)

Siv ib zaug ib hnub, tsis muaj kev txhaj tshuaj yuav tsum tau

Metabolic ruaj khov:

Ib nrab - lub neej ntawm 4-6 teev, haum rau ib leeg txhua hnub tswj hwm

Linear pharmacokinetics, koob tshuaj yog ib feem ntawm cov ntshav siab

Kawg Cov Khoom Qhia Khoom Siv Khoom Taw Qhia

1. Kev npaj ntawm cov ntsiav tshuaj ntawm qhov ncauj (10 mg / ntsiav tshuaj):

Piv Txwv Piv Txwv(rau 1000 ntsiav tshuaj):

GW0742 RAW KHOOM: 10.0g

Microcrystalline Cellulose: 80.0g

Lactose: 50.0g

Hla -} Txuas cov carboxymethyl cellulose sidium: 8.0g

Magnesium Stearate: 2.0g

Npaj txheej txheem:

Micronization Ntawm Cov Ntaub Ntawv Raw: D90 tsawg dua los yog sib npaug rau 10μm, txhim kho kev xaus lus

Cov nqi sib xyaw sib xyaw: maj mam sib tov tusyees nrog cov pab pawg

Ntub av granulle: granulate nrog cov nyiaj uas tsim nyog ntawm cov dej huv thiab qhuav ntawm 50 degree

Txawb: 8mm tuag, 8-10kn siab ntsiav tshuaj

Zaj duab xis txheej: Gastro - Soluble zaj duab xis txheej rau kev ruaj ntseg ruaj khov thiab palatability

2. Cov Qauv Tswj Xyuas Zoo:

Cov ntsiab lus sib xyaw: RSD tsawg dua lossis sib npaug rau 3% (HPLC Txujcual)

Tus lej sib cais: Ntau dua los yog sib npaug rau 85% hauv 30 feeb (duav txheej txheem, 50 rpm)

Lwm yam tshuaj: Ib leeg impurity tsawg dua los yog sib npaug rau 0.5%, tag nrho cov impurities tsawg dua los yog sib npaug rau 1.0%

Vim li cas thiaj xaiv GW0742 cov khoom siv raw?

Muaj kev xaiv PARP / Δ Agronist, Tshawb nrhiav cov cuab yeej

Ntau Cov Nyiaj Pab metabolic, Dual kev cai ntawm Lipid Metabolism thiab Qab Zib Metabolism

Cov chaw tshawb fawb dav, suav nrog cov kev siv ntau yam nyob hauv cov metabolism, kev tawm dag zog, thiab cov hlab plawv

Kev Muaj Peev Xwm Zoo:

GMP -} ua tiav ntau lawm, txhua pobHPLC Purity kuaj (loj dua lossis sib npaug rau 98%)

Thib peb - tog kab ke ceeb toom (COA)suav nrog cov khoom

Microbial txwv kuajTxhawm rau kom muaj kev nyab xeeb

Lub Ntiaj Teb Shipping:

Thawj Ntim Ntim Ntim, noo noo - ntawv pov thawj thiab lub teeb- ntawv pov thawj

Ntiav neeg, tsis muaj logo ntawm lub ntim sab nraud

Kub - kev thauj mus losTxhawm rau kom cov khoom ruaj khov

Tag

GW0742 yogIb qho kev ntsuas zoo tshaj plaws rau kev tshawb nrhiav rau hauv PARP / Δ kev pom txoj hauv kev, tshwj xeeb haum raukawm cov txheej txheem ntawm cov kab mob metabolic, tshawb nrhiav cov txheej txheem ntawm kev txhim kho cov kev tawm dag zog, thiab kawm txog kev tiv thaiv kab mob plawvCov. Kev Tshawb Xyuas Koob Yog3-10 mg / kg / hnub.

Xav taudab tsi, thov hu raupeb