Hauj lwm lawm

Kev tsis

Pregabalin (Pregabalin) Raw Khoom Hmoov Core Taw Qhia

Kws Tshuaj Ua Lag Luam Qib Khoom Qhua Khoom xyaw|Pregabalin (Gaba analog)

Tshuaj lom neeg npe: (S) -3- (Aminomethyl) -5-Methylhexanoic acid

Tus lej: 148553-50-8

Molecular Cov Lus: C₈h₁₇no₂

Molecular hnyav: 159.23

Melting taw tes: 186-188 degree

Zog: Dawb Crystalline Hmoov

Purity: ntau dua los yog sib npaug rau 99% (HPLC)

Cov teebmeem tseem ceeb

Pregabalin yog adab neeg calcium channel modulator uasyog siv davHauv kev kho mob ntawm kev mob neuropathic, kev kho kom haum rau kev mob vwm, thiab kev tswj hwm ntawm cov kev ntxhov siab ntxhov siabVim nwsCov tshuaj tiv thaiv kab mob anticonvulsant thiab analgesic zog.

✅ Precision kev kho mob ntawm neuralgia:

Txwv tsis pub muaj calcium calciumthiab txo cov kev tso tawm ntawm neurotransmitters xws li glutamate thiab norepinephrine

Mob ntshav qab zib neuropathy: Kev Kho Mob Tus Nqi Li Txog 50-60%

Postherpetic neuralgia: Cuam tshuam cov qhab nia mob

✅ Anti -} epileptic peruxiliary nyhuv:

Ib nrab Epileptic qaug dab peg: Kev kho kom raug kho kom zoo txo tau qaug dab peg zaus

Cov ntaub ntawv kev nyab xeeb zoo: syneroistic nrog cov tshuaj anti - epileptic tshuaj

✅ Kev ntxhov siab tswj hwm:

Kev ntxhov siab dav dav: Cov tsos mob ntxhov siab thiab txhim kho lub neej zoo

Cast - ua yeeb yam: Cov tsos mob txhim kho tuaj yeem muaj kev sib raug zoo hauv 1 lub lis piam

✅ Qhov Zoo:

Ntau cov ntawv qhia: Ib qho tshuaj rau ntau txoj kev kho, txhim kho kev lag luam tshuaj

Linear pharmacokinetics: Koob tshuaj yog ib ntu ntshav siab, ua kom nws yooj yim kho

Zoo -} pa}: Cov kev mob tshwm sim muaj mob hnyav thiab tus neeg mob ua tsaug ntau

Kawg Cov Khoom Qhia Khoom Siv Khoom Taw Qhia

1. Kev Npaj Hniav Ntsej Muag (25MG / Capsule, 75Mg / Capsule, 150mg / Capsule):

Piv txwv li qauv(1000 ntsiav tshuaj ntawm 75mg npaj):

Pregabalin Raw Khoom: 75.0G

Microcrystalline Cellulose: 50.0G

Lactose: 25.0g

Hla -}} Txuas sodium carboxymethyl cellulose: 5.0g

Magnesium Stearate: 1.5g

Npaj txheej txheem:

Cov Khoom Siv Raw Ua Ntej: Micronization (D90 tsawg dua los yog sib npaug rau 10μm)

Cov nqi sib xyaw sib xyaw: maj mam sib tov nrog rau dituent

Capsule Sau: TUAJ PUV PILLSULE FILLING TSHUAB puv

Polishing thiab Plua Plav Tshem Tawm: Capsule polishing tshuab tshem tawm cov hmoov hmoov

Aluminium -} Yas Ntim: noo noo - ntawv pov thawj thiab lub teeb- e} Cov ntawv pov thawj ntim

Kev Tswj Xyuas Zoo:

Cov ntsiab lus sib xyaw: RSD tsawg dua lossis sib npaug ntawm 3% (UV {{1} hplc nrhiav kom pom)

Tus lej sib cais: Ntau dua los yog sib npaug rau 80% hauv 30 feeb (duav txheej txheem, 50 rpm)

Lwm yam tshuaj: Ib leeg impurity tsawg dua los yog sib npaug rau 0.5%, tag nrho cov impurities tsawg dua los yog sib npaug rau 1.0%

2. Npaj Cov Kev Tshuaj Ntawm Qhov Ncauj (20 mg / ml):

Daim ntawv qhia piv txwv(Npaj ntim rau 100ml):

Pregabalin Raw Khoom: 2.0g

Sorbitol: 50.0g

Glycerol: 10.0g

Flavoring Tus Neeg Sawv Cev: Tus nqi uas tsim nyog

Lim dej lim: ntxiv rau 100ml

Cov kev siv raws tu qauv

1. Kev kho mob rau kev kho mob:

Pib koob tshuaj:

75 mg ob zaug ib hnub

lossis 150 mg ib hnub ib zaug

Koob tshuaj escalation:

Nce mus rau 300 mg / hnub tom qab 3-7 hnub raws li kev ua tau zoo thiab thev taus

Qhov tshuaj ntau tshaj plaws: 600 mg / hnub, muab faib ua 2-3 koob

Nqaum kho:

Feem ntau, nws yog ib qho tsim nyog yuav tsum tau siv nws tsis tu ncua rau 2-4 lub lis piam los ntsuas qhov ua tau zoo

Cov neeg uas ua tau zoo tuaj yeem ua kom txoj kev kho tau ntev ntev

2. Kev kho mob kom ncua rau kev mob vwm:

Cov Neeg Laus:

Thawj zaug: 75 mg ob zaug ib hnub

Kev Txij Nkawm: 150-600 mg / hnub, muab faib ua 2-3 koob

Cov Menyuam Tshuaj:

Yuav tsum xam raws li qhov hnyav thiab nruj ua raws li cov tswv yim kws kho mob

Qhov pib koob yog feem ntau 3.5 mg / kg / hnub

3. Generalized Ntxhov Siab Tsis Txaus Siab:

Pib koob tshuaj: 150 mg / hnub, muab faib ua 2 koob

Kho cov koob tshuaj: 300-600 mg / hnub

Kev Kho Mob: Feem ntau 4-6 lub lis piam ntawm kev kho tas mus li

4. Siv cov neeg tshwj xeeb:

Cov tsis muaj peev xwm:

Creatinine Duminance 30-60 ML / min: Ntau Npaum Ultrasonic Mg / Hnub

Creatinine Tshem Tawm 15-30 ml / min: Ultrasonic Ulce 150 Mg / Hnub

Creatinine tshem<15 ml/min: Maximum dose 75 mg/day

Cov neeg laus: Cov koob tshuaj kho raws li cov muaj nuj nqi raum

Hepatic tsis txaus: Me me rau nruab nrab, tsis muaj kev kho kom haum; siv nrog kev ceev faj hauv cov neeg mob hnyav

Vim li cas thiaj xaiv Pregabalin?

Ntau cov ntawv qhia: ib qho tshuaj rau ntau yam kev kho nrog rau neuralgia, qaug dab peg, thiab ntxhov siab

Ntshiab kev ua tau zoo: Cov kev tshawb fawb hauv chaw soj ntsuam tau ua pov thawj nws cov hauj lwm zoo

Yooj yim siv: ib zaug lossis ob zaug ib hnub, ua tiav zoo

Kev Muaj Peev Xwm Zoo:

GMP -} ua tiav ntau lawm, txhua pobHPLC Purity kuaj (loj dua lossis sib npaug rau 99%

Kev kawm ruaj khov: Kuaj tau nrawm rau 6 lub hlis ntsib tus qauv

Thib peb - tog kab ke ceeb toom (COA)suav nrog cov khoom

Kev Ntim:

Noog noo -} Cov ntaub ntawv pov thawj thiab lub teeb- ntawv pov thawj ntim: Aluminium Ntawv Nyiaj Hnab + Desiccant

Kub tswj kev thauj: thauj ntawm 15-25 degree

Kev pub dawb ntiag tug: Tsis muaj cov ntaub ntawv rhiab ntawm cov ntim sab nraud

Tag

Pregabalin yogIb qho kev xaiv tseem ceeb rau kev kho cov kab mob neurological, tshwj xeeb haum rauneuropathic qhov kev tswj hwm qhov mob nyhav, kev hloov kho mob kis mob vwm, thiab ntxhov siab vim tswj tauCov. Cov koob tshuaj pom zoo yog150-600mg / hnub.

Xav tau phiaj xwm npaj phiaj xwm tshwj xeeb?

Peb muab cov kev coj ua kev tshaj lij los pab koj npaj cov khoom kawg kom nyab xeeb thiab zoo!

Xav taudab tsi, thov hu raupeb