Prostamax 20mg / vial Txhawb nqa Prostate Health

Prostamax 20mg / lub raj mis qhia

Pharmaceutical -qib peptide formulations|Ua nyob rau hauv Suav teb, prostate noj qab haus huv- phiaj peptide 20mg/vial

Specifications20mg / lub raj mis, 5 fwj / lub thawv

Purity: Ntau dua lossis sib npaug li 99% (HPLC kuaj pom)

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: Txias ntawm 2-8 degree, tiv thaiv los ntawm lub teeb. Siv nyob rau hauv 7 hnub tom qab reconstitution.

Core zoo thiab muaj nuj nqi

Prostamax yog ibcov ntaub so ntswg prostate- tsom rau kev tswj peptideuas qhia txog tus nqi tshwj xeeb hauv cov teb ntawmbenign prostatic hyperplasia (BPH) kev tshawb fawb, kev kho mob ntawm prostate, thiab kev tshawb fawb urinary systemlos ntawmtshwj xeeb tshaj yog tswj cov prostate cell proliferation, apoptosis, thiab inflammatory teb txoj kev. Nws yog cov cuab yeej tseem ceeb peptide rau kev tshawb fawb urological thiab txiv neej.

✅Prostatetswj mechanism:

Kev tswj hwm ntawm cell proliferation: tswj lub voj voog loj hlob ntawm prostate epithelial hlwb thiab cov leeg nqaij du

Inflammation teb suppression: Kev txo qis ntawm pro- cov kab mob inflammatory xws li TNF- , IL-6, thiab COX-2 hauv cov ntaub so ntswg prostate

Kev tiv thaiv kev ntxhov siab oxidative: Txhim kho cov tshuaj tiv thaiv antioxidant ntawm prostate hlwb

Kev tswj ntawm angiogenesis: Tswj kev qhia ntawm vascular endothelial kev loj hlob zoo (VEGF)

✅Qualityqhov zoo ntawm Suav manufacturers:

Tsim ib ntus: Optimized Design Raws li Prostate -Specific Membrane Antigen (PSMA) Target Sequences

Synthesis txheej txheem: Fmoc khoom-xeev synthesis ua ke nrog microwave-pab synthesis technology

Purification tswj: Npaj HPLC ua ke nrog thim rov qab -theem chromatography, lub ntsiab ncov purity Ntau dua lossis sib npaug li 99.5%.

Kev ua validation: Dual validation siv nyob rau hauv vitro prostate cell qauv thiab tsiaj qauv

Aseptic ntau lawm: Chav Kawm C huv ib puag ncig, automated filling thiab khov - tshuab ziab khaub ncaws

Cov ntaub ntawv tswj xyuas zoo: Muab cov ntaub ntawv kawm tiav (CMC cov ntaub ntawv pob).

✅ khoomNta:

Lub hom phiaj: Tshwj xeeb heev rau cov ntaub so ntswg prostate

Metabolic stability: Txhim kho enzymatic hydrolysis stability los ntawm D-amino acid hloov.

Muaj zog nkag: Optimized lipid solubility txhim khu cov ntaub so ntswg muaj peev xwm.

Zoo kev nyab xeeb profile: Cov kev tshawb fawb txog kev nyab xeeb hauv tsev kho mob qhia tau hais tias kho tau zoo.

Daim ntawv qhia kev siv thiab cia

1. Kev kho dua tshiab thiab kev npaj:

Kev xaiv cov kuab tshuaj:

Thawj qhov kev xaiv:Sterile saline

Kev tshawb fawb hauv vitro:serum- pub dawb cell culture media(RPMI-1640, DMEM, thiab lwm yam)

Kev kawm tshwj xeeb:PBS tsis muaj 1-2% BSA

Standard configuration:

Ncuav 2 mL ntawm cov kuab tshuaj rau hauv 20 mg vial thiab maj mam swirl kom yaj.

Ib qho kev daws teeb meem ntawm10 mg/mlua tau.

Rau qis concentrations, dilute maj mam nrog cov kuab tshuaj tsim nyog.

Dissolving Notes:

Lub sij hawm dissolving: Kwv yees li 3-5 feeb kom tiav dissolution.

Kev soj ntsuam: Cov tshuaj yuav tsum yog qhov tseeb thiab pob tshab, tsis muaj cov khoom me me.

Contraindications: Tsis txhob tuav lub zog, kev kho ultrasonic, lossis cua sov kom yaj.

2. Cia tej yam kev mob:

Tsis qhib:

Khaws ntawm 2-8 degreerau 24 lub hlis.

Khaws khov ntawm -20 degreerau 36ay.

Tsis txhob rov khov dua -thaw cycles

Rov tsim dua:

Kev daws teeb meem: ruaj khovrau 7 hnub thaum lub tub yees ntawm 2-8 degree.

Kev daws teeb meem: Nws raug nquahu kom npaj thiab siv tam sim ntawd, thiab khaws cia ntawm 4℃tsis pub ntau tshaj 24 teev.

Rau lub sijhawm ntev - khaws cia, rov ntim dua thiab khov ntawm -20℃.

Kev thauj mus los:

Kev thauj mus los txias (2-8 degree)

Siv qhov ntsuas kub tshaj lij- tswj kev ntim khoom

Tshawb xyuas cov khoom tam sim ntawd thaum tuaj txog thiab khaws cia raws li qhov xav tau.

ruaj khov:

Feem ntau ruaj khov ntawm pH 6.5-7.5

Kub rhiab heev: Tsis txhob kub siab tshaj 37 degree

Photosensitivity: rhiab heev rau lub teeb ultraviolet, yuav tsum tuav thaum tsis muaj lub teeb.

3. Kev tshawb fawb thiab kev npaj ua ntawv thov:

Kev sim hauv vitro cell:

Pom zoo concentration:0.1-10 µM

Lub sijhawm ua haujlwm:24, 48, 72 h

Cell hom:

Tib neeg prostate epithelial hlwb (RWPE-1)

Human prostate cancer hlwb (LNCaP, PC-3)

Prostate fibroblasts

Kev ntsuas ntsuas:

Kev loj hlob ntawm tes (CCK-8, MTT)

Apoptosis (Annexin V/PI)

Cell voj voog (PI staining flow cytometry)

Inflammatory factors (ELISA, qPCR)

Tsiaj hauv vivo kev tshawb fawb:

Kev pom zoo qauv:

Testosterone-induced benign prostatic hyperplasia (BPH) nas qauv

Spontaneous BPH qauv (cov laus dev)

Prostatitis qauv

Txoj kev tswj hwm:

Kev txhaj tshuaj subcutaneous:0.5-2.0 mg / kg, ib hnub ib zaug.

Intraperitoneal txhaj tshuaj:0.2-1.0 mg / kg, ib hnub ib zaug.

Kev tswj qhov ncauj: yuav tsum muaj kev xa khoom tsim nyog.

Dosage regimen:

Cov tshuaj tiv thaiv kab mob: Pib 1 lub lis piam ua ntej ua qauv thiab txuas ntxiv rau 4-8 lub lis piam.

Kev tswj hwm kev kho mob: Pib tom qab ua qauv thiab txuas ntxiv rau 2-6 lub lis piam.

Kev ntsuas ntsuas:

Prostate index (prostate hnyav / lub cev hnyav)

Histopathology (HE staining, Masson staining)

Ntshav qab zib PSA qib

Urodynamics

Inflammatory factor qhia

Mechanism ntawm kev kawm ua:

Txoj kev taw qhia: Wnt/ -catenin, TGF- /Smad, NF-κB

Cov tshuaj hormones metabolism: 5 -reductase thiab aromatase cov dej num

Extracellular matrix: Collagen deposition,℃ntawm fibrosis

Angiogenesis: Microvessel ceev, VEGF qhia

4. Cov tswv yim tsim kev sim:

Kev tshawb nrhiav tshuaj:

Tsawg- pawg koob tshuaj: 0.1 mg/kg

Cov koob tshuaj nruab nrab: 0.5 mg / kg

Siab - pawg koob tshuaj: 2.0 mg/kg

Tswj pab pawg teeb tsa:

Kev tswj tsis pub muaj: physiological saline

Kev sib piv ntawm tus qauv: qauv + hnyav

Kev tswj qhov zoo: finasteride (5 mg / kg) lossis doxazosin (0.5 mg / kg)

Lub sijhawm ua piv txwv:

luv-cov teebmeem: 1-7 hnub tom qab kev tswj hwm

Nruab nrab-cov nyhuv: 2-4 lub lis piam tom qab kev tswj hwm

Ntev -cov teebmeem: 6-8 lub lis piam tom qab kev tswj hwm

Qauv ua:

Prostate cov ntaub so ntswg: tsau nrog 4% paraformaldehyde (pathological), flash- khov hauv kua nitrogen (molecular).

Serum: Khaws ntawm -80℃tom qab sib cais.

Cov zis: Freshly kuaj los yog khaws cia ntawm -20 degree

Vim li cas thiaj xaiv Prostamax, ua hauv Suav teb?

Technicalqhov zoo:

Muaj peev xwm tsim kev ywj pheej rau prostate -peptides tshwj xeeb.

Mature chemical modification techniques txhim khu kev ruaj ntseg

Ib qho kev tshuaj ntsuam xyuas kev ua si thiab kev siv tau zoo platform

Zoolav:

Kev tswj cov khoom siv nruj nruj: saib xyuas tag nrho cov txheej txheem los ntawm cov khoom pib mus rau cov khoom tiav.

Cov cuab yeej tshuaj ntsuam xyuas qib siab: UPLC-MS/MS, CD, NMR, thiab lwm yam.

Ua kom tiav kev kawm ruaj khov: nrawm thiab ntev - cov ntaub ntawv ruaj khov

Nqiqhov zoo:

Loj -scale ntau lawm txo cov nqi tsev

Cov nqi yog 30-50% qis dua li cov khoom lag luam zoo sib xws.

Muab cov ntim customized thiab cov kev xaiv loj.

Kev pabcuamTxhawb nqa:

Pab neeg tshaj lij technical support

Muab cov ncauj lus kom ntxaws txog kev sim raws tu qauv siv

Kev ua tiav tom qab - muag kev pabcuam

Teb sai sai rau cov neeg siv khoom xav tau

Tshawb nrhiav thiab siv cov lus qhia

Basic kev tshawb fawb teb:

Molecular regulatory mechanisms ntawm prostate kev loj hlob

Hormone-dependent thiab non-hormone-dependent txoj kev loj hlob

Prostate microenvironment thiab kab mob kev loj hlob

Kev sib raug zoo ntawm o thiab benign prostatic hyperplasia

Kev txhais tshuaj tshawb fawb:

Kev tsim kho tshiab cov tswv yim kho mob rau cov kab mob prostate

Tsim thiab ntsuam xyuas cov phiaj xwm xa tshuaj

Optimization ntawm kev sib xyaw ua ke kev kho mob

Nrhiav thiab validation ntawm biomarkers

Kev tshawb fawb Preclinical:

Kev siv tshuaj zoo thiab kev soj ntsuam kev nyab xeeb

Pharmacokinetic / Pharmacodynamic Studies

Lub mechanism ntawm kev txiav txim tau elucidated nyob rau hauv qhov tob.

Txiav txim siab qhov zoo tshaj plaws kev noj tshuaj

Cov ntsiab lus

Prostamax embodies Tuam Tshoj cov thev naus laus zis ua tiav hauvkev tshawb fawb thiab kev txhim kho ntawm cov zis - cov tshuaj peptide tsom. Los ntawm kev tsim peptide tshiab, tswj kev tsim khoom nruj, thiab kev ua haujlwm tau zoo, peb muabsiab -zoo, cov cuab yeej tshawb fawb zoo heev rau cov kws kho mob urologist thiab cov kws tshawb fawb txog kev noj qab haus huv ntawm txiv neej thoob ntiaj teb. Cov khoom no muaj txiaj ntsig tseem ceeb hauv daim ntawv thovKev tshawb fawb yooj yim thiab kev tsim tshuaj rau cov kab mob prostatethiab xav tias yuav tsav kev kawm txuj ci hauv daim teb no.

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