Bronchogen 20mg / vial Optimize Respiratory Function

Bronchogen 20mg / lub raj mis qhia

Pharmaceutical -qib peptide formulation|Ua nyob rau hauv Tuam Tshoj bronchial kho thiab regeneration peptide 20mg / vial

Specifications20mg / lub raj mis, 5 fwj / lub thawv

Purity: Ntau dua lossis sib npaug li 99% (HPLC kuaj pom)

Qhov tshwm sim: Dawb lyophilized hmoov

Cia: Khaws khov ntawm -20℃deb ntawm lub teeb; Tom qab thawing, refrigerate ntawm 2-8 degrees.

Core zoo thiab muaj nuj nqi

Bronchogen yog ibhluavtaws peptide uas lub hom phiaj kho txoj hlab cua thiab rov tsim dua tshiab. Los ntawmtshwj xeeb tswj cov kab mob hauv cov hlab ntsws, txhawb kev kho epithelial, thiab txhim kho lub ntsws ua haujlwm, nws muaj nuj nqis siv tseem ceeb hauvkev kho mob ntawm cov kab mob ua pa ntev, kho lub ntsws raug mob, thiab cov tshuaj ua pa regenerative.Nws yogib lub cuab yeej tshawb fawb tseem ceeb hauv kev tshawb nrhiav tshuaj ua pa thiab tshuaj txhais lus.

✅Bronchialkho mechanism:

Anti-cov teebmeem inflammatory: Inhibits NF-κB thiab MAPK inflammatory signaling pathways

kho epithelial: Txhawb txoj kev loj hlob thiab kev tsiv teb tsaws ntawm cov hlab ntsha epithelial hlwb

Mucus kev cai: Tswj mucin secretion thiab ciliary clearance muaj nuj nqi.

Anti- fibrotic: Inhibits airway fibroblast transformation thiab collagen deposition

Kev tiv thaiv kab mob: tswj Th1/Th2 cell homeostasis thiab cytokine secretion

✅Qualityqhov zoo ntawm Suav manufacturers:

Tsim ib ntus: Kev Tsim Nyog Tsim Nyog Raws Li Cov Khoom Uas Muaj Feem Uas Ua Rau Kev Loj Hlob

Synthesis txheej txheem: Fmoc solid-theem synthesis ua ke nrog kua-theem synthesis technology

Purification tswj: Npaj HPLC ua ke nrog ion- pauv chromatography, purity Ntau dua lossis sib npaug li 99.5%.

Kev ua validation: Dual validation siv ib qho in vitro airway epithelial cell qauv thiab tus qauv hauv vivo mob ntsws.

Aseptic ntau lawm: Chav tsev C huv, tag nrho automated filling thiab khov - tshuab ziab khaub ncaws

Cov ntaub ntawv tswj xyuas kom zoo: Ua kom tiav cov ntaub ntawv kawm zoo (CMC cov ntaub ntawv pob) + cov ntaub ntawv ruaj khov

✅ khoomNta:

Airway phiaj xwm: muaj qhov tshwj xeeb affinity rau cov ntaub so ntswg ua pa

Siab ruaj khov: Enzyme stability yog txhim kho los ntawm D-amino acid thiab acetylation hloov kho.

Zoo kev nyab xeeb profile: Preclinical toxicology cov kev tshawb fawb qhia pom lub qhov rais dav dav.

Synergistic nyhuv: tuaj yeem siv ua ke nrog bronchodilators thiab glucocorticoids.

Daim ntawv qhia kev siv thiab cia

1. Kev kho dua tshiab thiab kev npaj:

Kev xaiv cov kuab tshuaj:

Thawj qhov kev xaiv:Sterile saline

Kev tshawb nrhiav hauv vitro:serum{0}} dawb DMEM/F12 nruab nrab

Daim ntawv thov Nebulization:Sterile dej rau kev txhaj tshuaj

Standard configuration:

Ncuav 2 mL ntawm cov kuab tshuaj rau hauv 20 mg vial thiab maj mam swirl kom yaj.

Ib qho kev daws teeb meem ntawm10 mg/mlua tau.

Maj mam dilute mus rau qhov ua haujlwm concentration siv cov kuab tshuaj tsim nyog.

Kev tswj kev tawg:

Dissolution tej yam kev mob: Dissolve nyob rau hauv chav tsev kub nyob rau hauv qhov tsaus ntuj nti rau 5-8 feeb.

Cov khoom siv tshuaj: ntshiab thiab pob tshab, tsis muaj cov khoom.

pH qhov xav tau: kawg pH 6.8-7.4

Nebulizing tov: Dilute nrog physiological saline rau 1-2 mg / mL ua ntej siv.

2. Cia tej yam kev mob:

Tsis qhib:

Txias ntawm -20 degree: tuaj yeem khaws ciarau 24 lub hlis

-80℃sib sib zog nqus khov: tuaj yeem khaws ciarau 36ay

Tsis txhob rov khov dua -thaw cycles (tsawg dua lossis sib npaug li 3 zaug).

Rov tsim dua:

Kev daws teeb meem: ruaj khovrau 5 hnub thaum lub tub yees ntawm 4 degree.

Kev daws teeb meem: Nws raug pom zoonpaj thiab siv tam sim ntawd, thiab khaws cia ntawm 4℃tsis pub ntau tshaj 24 teev.

Nebulizing kua: Siv tam sim tom qab kev npaj.

Kev thauj mus los:

Kev thauj dej khov qhuav (hauv qab -78 degree)

Professional frozen thauj ntim

Nruab nrog cov khoom siv ntsuas kub

Stability parameters:

Kub rhiab heev: Degradation yog nrawm ntawm qhov kub siab tshaj 37 degree.

pH stability: 6.8-7.4 yog qhov pom zoo.

Photosensitivity: Sensitive rau ultraviolet lub teeb

Oxidation rhiab heev: Tsis txhob sib cuag nrog oxidants

3. Kev tshawb fawb thiab kev npaj ua ntawv thov:

Kev sim hauv vitro cell:

Cell qauv:

Human airway epithelial cells (16HBE, BEAS-2B)

Primary airway epithelial cells

Mob ntsws fibroblasts

alveolar macrophages

Concentration gradient:

Tsawg concentration: 0.1-1 ug / mL

Medium concentration: 1-10 ug / mL

Cov ntsiab lus siab: 10-50 ug / ml

Lub sijhawm ua haujlwm:

Kev mob tshwm sim: 1-6 teev (mob mob tshwm sim)

Nruab nrab- lub sij hawm nyhuv: 12-48 teev (gene kho)

Ntev -cov teebmeem: 72-120 xuab moos (barrier function)

Kev ntsuas ntsuas:

Cell viability: CCK-8, LDH tso tawm

Inflammatory factors: IL-6, IL-8, TNF-

Barrier muaj nuj nqi: Transepithelial tsis kam (TEER)

Molecular mechanism: Western blot, immunofluorescence

Tsiaj hauv vivo kev tshawb fawb:

Kab mob qauv:

Tus qauv mob ntsws asthma: OVA rhiab heev thiab kev sib tw

COPD qauv: Cov pa luam yeeb raug

Pulmonary fibrosis qauv: bleomycin induction

Tus qauv mob ntsws raug mob: LPS induction

Txoj kev tswj hwm:

Nebulized inhalation:1-2 mg / kg, ib hnub ib zaug.

Intracheal infusion:0.5-1.0 mg / kg, ib zaug ib hnub twg.

Intraperitoneal txhaj tshuaj:0.2-0.5 mg / kg, ib hnub ib zaug.

Kev txhaj tshuaj intravenous:0.1-0.3 mg / kg, ib hnub ib zaug.

Dosage regimen:

Prophylactic kev tswj hwm: Pib 1 lub lis piam ua ntej tsim qauv

Kev tswj hwm kev kho mob: Pib tom qab tsim qauv

Lub sijhawm kho: 7-28 hnub

Kev ntsuas ntsuas:

Lub ntsws ua haujlwm: ua pa tsis ua haujlwm, ua raws lub ntsws

Kev ntsuam xyuas mob: BALF cell suav, cytokines

Pathology: Nws staining, Masson staining

Airway hyperresponsiveness: methacholine stimulation

Mechanism ntawm kev kawm ua:

Kev taw qhia txoj hauv kev: NF-κB, MAPK, STAT

Oxidative stress: MDA, SOD, GSH

Apoptosis: TUNEL, Caspase-3

Autophagy tswj: LC3, p62

4. Kev sim tsim kom zoo:

Kev xaiv noj tshuaj:

Cov koob tshuaj tsawg: 0.2 mg / kg

Qhov nruab nrab koob tshuaj: 1.0 mg / kg

Cov koob tshuaj ntau: 2.0 mg / kg

Tswj pab pawg teeb tsa:

Kev tswj tsis pub muaj: physiological saline

Kev sib piv qauv: Kab mob qauv + hnyav

Kev tswj qhov zoo: Dexamethasone (1 mg / kg)

Time point design:

Kev mob tshwm sim: 6-72 teev tom qab kev tswj hwm

Subacute theem: 1-2 lub lis piam

Lub sij hawm ntev: 2-4 lub lis piam

Qauv sau:

BALF: Bronchoalveolar Lavage Fluid

Lub ntsws cov ntaub so ntswg: kho nrog 4% paraformaldehyde / flash- khov hauv kua nitrogen

Serum: Khaws ntawm -80℃tom qab sib cais.

Kev kuaj xyuas txoj kev:

Kev kuaj lub ntsws ua haujlwm

Histopathological qhab nia

Immunohistochemical tsom xam

Kev tshawb nrhiav molecular biological

Vim li cas thiaj xaiv Bronchogen, ua hauv Suav teb?

Technicalqhov zoo:

Autonomous tsim muaj peev xwm ntawm kev ua pa - phiaj peptides

Advanced atomized formulation technology

Ib qho kev nthuav dav kab mob ua pa qauv platform

Kev tshawb fawb pharmacokinetic

Zoolav:

nruj raw khoom thiab kev tswj cov txheej txheem

Advanced analytical thiab xeem cov cuab yeej

Ua tiav kev kawm ruaj khov

High sib xws ntawm batch

Kev pabcuamTxhawb nqa:

Pab neeg tshaj lij technical support

Cov lus qhia ntxaws txog daim ntawv thov kev daws teeb meem

Kev txhawb nqa ntaub ntawv thiab kev sib tham txog kev tshawb fawb

Customized peptide kev pabcuam hloov kho

Nqi-kev ua tau zoo:

Loj -scale ntau lawm txo nqi

Piv nrog rau cov khoom siv txawv teb chaws, lawv muaj tus nqi meej.

Kev xaiv ntim yooj yim

Cov ntsiab lus

Bronchogen sawv cev rau Tuam Tshoj txoj kev vam meej hauvkev tshawb fawb ntawm kev kho peptides rau cov kab mob ua pa. Los ntawm kev tsim cov txheej txheem tshiab, cov txheej txheem tsim khoom nruj, thiab kev siv tshuaj kho mob tau zoo, nws muab cov cuab yeej tshawb fawb siab - zoo, muaj zog heevrau kev tshawb fawb tshuaj ua pa thoob ntiaj teb. Cov khoom no muaj txiaj ntsig tseem ceeb hauv daim ntawv thovkev kawm txog cov kab mob ua pa mechanisms thiab kev tsim tshuaj, pab txhawb kev nce qib ntawm thaj chaw ntawm kev ua pa.

Need dab tsi, thov hu raupeb

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